benzyloxycarbonyl-tauryl-(N-methyl)-L-phenylalanine methyl ester | 885695-35-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyloxycarbonyl-tauryl-(N-methyl)-L-phenylalanine methyl ester
• CAS: 885695-35-2
• 化学式: C₂₁H₂₆N₂O₆S
• 分子量: 434.513
• InChiKey: FYQCBSOVVIXQQA-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  30.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  102.01
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  benzyloxycarbonyl-tauryl-(N-methyl)-L-phenylalanine methyl ester 、 三氟乙酸 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  α-Peptide/β-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-Met-Leu-Phe-OMe

  摘要：

  In order to gain information on the activity shown by alpha-peptide/beta-sulfonamidopeptide hybrid analogs of the potent chemotactic agent fMLF-OMe, a structure-activity study is reported on N-Boc- and N-formyl tripeptide models containing an aminoalkanesulfonic acid as central residue. Directed migration (chemotaxis), superoxide anion production, and lysozyme release have been measured. The biochemical functions and the conformational properties of the new compounds are discussed and related to previously Studied models containing P-residues. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.11.043
• 作为产物：
  描述：

  氯甲酸苄酯 在 sodium hydroxide 、 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 benzyloxycarbonyl-tauryl-(N-methyl)-L-phenylalanine methyl ester
  参考文献：
  名称：

  α-Peptide/β-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-Met-Leu-Phe-OMe

  摘要：

  In order to gain information on the activity shown by alpha-peptide/beta-sulfonamidopeptide hybrid analogs of the potent chemotactic agent fMLF-OMe, a structure-activity study is reported on N-Boc- and N-formyl tripeptide models containing an aminoalkanesulfonic acid as central residue. Directed migration (chemotaxis), superoxide anion production, and lysozyme release have been measured. The biochemical functions and the conformational properties of the new compounds are discussed and related to previously Studied models containing P-residues. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.11.043