2-oxo-6-(phenyldiazenyl)-2H-chromene-3-carbohydrazide | 1243242-68-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-oxo-6-(phenyldiazenyl)-2H-chromene-3-carbohydrazide
• CAS: 1243242-68-3
• 化学式: C₁₆H₁₂N₄O₃
• 分子量: 308.296
• InChiKey: BCQPXLQYZPBIFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.81
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  110.05
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2-oxo-6-(phenyldiazenyl)-2H-chromene-3-carbohydrazide 、 异氰酸对硝基苯 以 乙腈 为溶剂， 以76%的产率得到1-(4-Nitrophenyl)-3-[(2-oxo-6-phenyldiazenylchromene-3-carbonyl)amino]urea
  参考文献：
  名称：

  A novel colorimetric and fluorescence anion sensor with a urea group as binding site and a coumarin group as signal unit

  摘要：

  A novel colorimetric and fluorescent anion sensor based on urea substituted with a coumarin moiety and a pendant phenylazo unit was synthesized and evaluated according to the binding site-signalling subunit approach. The azo group was exploited as the chromogene, the urea moiety providing the anion binding site and the coumarin system was responsible for fluorescence. As such, the dye enabled visual detection of acetate ion in DMSO (color change light yellow to red) without resorting to spectroscopic instrumentation. More importantly, the sensor displayed significant fluorescence enhancement response to anions such as acetate, because of complex formation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.04.007
• 作为产物：
  描述：

  ethyl 2-oxo-6-(phenyldiazenyl)-2H-chromene-3-carboxylate 在 肼 作用下， 以 乙醇 为溶剂， 以45%的产率得到2-oxo-6-(phenyldiazenyl)-2H-chromene-3-carbohydrazide
  参考文献：
  名称：

  A novel colorimetric and fluorescence anion sensor with a urea group as binding site and a coumarin group as signal unit

  摘要：

  A novel colorimetric and fluorescent anion sensor based on urea substituted with a coumarin moiety and a pendant phenylazo unit was synthesized and evaluated according to the binding site-signalling subunit approach. The azo group was exploited as the chromogene, the urea moiety providing the anion binding site and the coumarin system was responsible for fluorescence. As such, the dye enabled visual detection of acetate ion in DMSO (color change light yellow to red) without resorting to spectroscopic instrumentation. More importantly, the sensor displayed significant fluorescence enhancement response to anions such as acetate, because of complex formation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.04.007