2-deuterio-(Z)-1,4-bis(4-methoxyphenyl)but-1-en-3-yne | 1403477-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-deuterio-(Z)-1,4-bis(4-methoxyphenyl)but-1-en-3-yne
• 英文别名: 1-[(Z)-2-deuterio-4-(4-methoxyphenyl)but-1-en-3-ynyl]-4-methoxybenzene
• CAS: 1403477-10-0
• 化学式: C₁₈H₁₆O₂
• 分子量: 265.316
• InChiKey: ZXJWFXWCDJZTRS-ZUDMJWGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-bis(4-methoxyphenyl)-1,3-butadiyne 在 乙基溴化镁 、 iron(II) chloride 、 重水 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 0.25h， 以56%的产率得到
  参考文献：
  名称：

  Iron-Catalyzed Chemo- and Stereoselective Hydromagnesiation of Diarylalkynes and Diynes

  摘要：

  Diarylalkynes are chemo- and stereoselectively hydromagnesiated in high yields at room temperature with an iron species generated in situ from FeCl2 and EtMgBr. Functional groups such as bromide, iodide, amine, phenoxide, and alkene are well tolerated. Under similar conditions, diynes are chemo-, regio-, and stereoselectively hydromagnesiated. The resulting alkenylmagnesium compounds are a platform for further functionalization as a one-pot reaction.

  DOI：

  10.1021/ja307631v

文献信息

• Iron-Catalyzed Chemo- and Stereoselective Hydromagnesiation of Diarylalkynes and Diynes
  作者：Laurean Ilies、Takumi Yoshida、Eiichi Nakamura

  DOI：10.1021/ja307631v

  日期：2012.10.17

  Diarylalkynes are chemo- and stereoselectively hydromagnesiated in high yields at room temperature with an iron species generated in situ from FeCl2 and EtMgBr. Functional groups such as bromide, iodide, amine, phenoxide, and alkene are well tolerated. Under similar conditions, diynes are chemo-, regio-, and stereoselectively hydromagnesiated. The resulting alkenylmagnesium compounds are a platform for further functionalization as a one-pot reaction.