2-(6-allyl-6,7-dihydro-5H-dibenz[c,e]azepin-5-yl)acrylonitrile | 1611486-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-(6-allyl-6,7-dihydro-5H-dibenz[c,e]azepin-5-yl)acrylonitrile
• CAS: 1611486-09-9
• 化学式: C₂₀H₁₈N₂
• 分子量: 286.376
• InChiKey: CQSQZCKDXIZENK-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(6-allyl-6,7-dihydro-5H-dibenz[c,e]azepin-5-yl)acrylonitrile 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以62%的产率得到7,9-dihydro-4bH-dibenz[c,e]pyrrolo[1,2-a]azepine-5-carbonitrile
  参考文献：
  名称：

  An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita–Baylis–Hillman adducts

  摘要：

  An acid-catalyzed modular synthesis of substituted 5H-dibenz[c,e]azepines from a biaryl allylbenzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility of the product for preparing 7,9-dihydro-4bH-dibenz[c,e]pyrrolo[1,2-alpha]azepine is also presented. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.055
• 作为产物：
  描述：

  2-(5H-dibenz[c,e]azepin-5-yl)acrylonitrile 在 sodium cyanoborohydride 、 potassium carbonate 、 溶剂黄146 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 2-(6-allyl-6,7-dihydro-5H-dibenz[c,e]azepin-5-yl)acrylonitrile
  参考文献：
  名称：

  An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita–Baylis–Hillman adducts

  摘要：

  An acid-catalyzed modular synthesis of substituted 5H-dibenz[c,e]azepines from a biaryl allylbenzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility of the product for preparing 7,9-dihydro-4bH-dibenz[c,e]pyrrolo[1,2-alpha]azepine is also presented. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.055