(S)-2-(1-ethoxyethoxy)-1-propyl mesylate | 960615-62-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (S)-2-(1-ethoxyethoxy)-1-propyl mesylate
• 英文别名: [(2S)-2-(2-ethoxyethoxy)propyl] methanesulfonate
• CAS: 960615-62-7
• 化学式: C₈H₁₈O₅S
• 分子量: 226.294
• InChiKey: NHRSAGQEQKPGRZ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-2-(1-ethoxyethoxy)-1-propyl mesylate 在 正丁基锂 、 sodium phosphide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 生成 (S,S,S)-tris[2-(1-ethoxyethoxy)-2-methylethyl]phosphine borane complex
  参考文献：
  名称：

  (R,R,R)-Tris(2-hydroxy-1-methylethyl)- and (S,S,S)-tris(2-hydroxy-2-methylethyl)phosphine: water-soluble chiral trialkylphosphines with C3-symmetry

  摘要：

  The first alpha- and beta-chiral water-soluble trialkylmonophosphines, 1 and 2, respectively, both with C-3 symmetry, were synthesised from sodium phosphide and chiral mesylates, accessible from (S)-ethyl lactate. X-ray structures of a corresponding 2:1 gold(I) Complex [1(2)Au(1)]OTf and of a borane complex 2.BH3 were determined. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.06.030
• 作为产物：
  描述：

  (S)-2-ethoxyethyl-1,2-propanediol 、 甲基磺酰氯 在 吡啶 作用下， 反应 16.0h， 以84%的产率得到(S)-2-(1-ethoxyethoxy)-1-propyl mesylate
  参考文献：
  名称：

  (R,R,R)-Tris(2-hydroxy-1-methylethyl)- and (S,S,S)-tris(2-hydroxy-2-methylethyl)phosphine: water-soluble chiral trialkylphosphines with C3-symmetry

  摘要：

  The first alpha- and beta-chiral water-soluble trialkylmonophosphines, 1 and 2, respectively, both with C-3 symmetry, were synthesised from sodium phosphide and chiral mesylates, accessible from (S)-ethyl lactate. X-ray structures of a corresponding 2:1 gold(I) Complex [1(2)Au(1)]OTf and of a borane complex 2.BH3 were determined. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.06.030

文献信息

• (R,R,R)-Tris(2-hydroxy-1-methylethyl)- and (S,S,S)-tris(2-hydroxy-2-methylethyl)phosphine: water-soluble chiral trialkylphosphines with C3-symmetry
  作者：Peter Kasák、Vladimir B. Arion、Michael Widhalm

  DOI：10.1016/j.tetlet.2007.06.030

  日期：2007.8

  The first alpha- and beta-chiral water-soluble trialkylmonophosphines, 1 and 2, respectively, both with C-3 symmetry, were synthesised from sodium phosphide and chiral mesylates, accessible from (S)-ethyl lactate. X-ray structures of a corresponding 2:1 gold(I) Complex [1(2)Au(1)]OTf and of a borane complex 2.BH3 were determined. (c) 2007 Elsevier Ltd. All rights reserved.