3-Chloro-N-[(phenylmethoxy)carbonyl]-L-tyrosine | 749268-85-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Chloro-N-[(phenylmethoxy)carbonyl]-L-tyrosine
• 英文别名: (2S)-3-(3-chloro-4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoic acid
• CAS: 749268-85-7
• 化学式: C₁₇H₁₆ClNO₅
• 分子量: 349.8
• InChiKey: OZTJANAAQUIGNE-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] A METABOLITE PANEL FOR IMPROVED SCREENING AND DIAGNOSTIC TESTING OF CYSTIC FIBROSIS<br/>[FR] PANEL DE MÉTABOLITES POUR TEST DE DÉPISTAGE ET DE DIAGNOSTIC AMÉLIORÉ DE LA MUCOVISCIDOSE
  申请人：UNIV MCMASTER

  公开号：WO2015179952A1

  公开（公告）日：2015-12-03

  A novel method of diagnosing cystic fibrosis in a human subject is provided. The method includes the steps of: i) determining in a biological sample from the subject the level of one or more metabolic biomarkers; ii) comparing the level of the biomarker to a control level and determining the difference between the biomarker level and the control level; and iii) determining that the subject has cystic fibrosis or a related disorder when the difference in the level of the biomarker in the sample is statistically different from the control level.