1-[(Benzyloxycarbonylamino-methyl)-methoxy-phosphinoylmethyl]-cyclopentanecarboxylic acid tert-butyl ester | 182048-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(Benzyloxycarbonylamino-methyl)-methoxy-phosphinoylmethyl]-cyclopentanecarboxylic acid tert-butyl ester
• CAS: 182048-45-9
• 化学式: C₂₁H₃₂NO₆P
• 分子量: 425.462
• InChiKey: OWEBZZREAOWNRD-UHFFFAOYSA-N

物化性质

• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  90.93
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  1-[(Benzyloxycarbonylamino-methyl)-methoxy-phosphinoylmethyl]-cyclopentanecarboxylic acid tert-butyl ester 在 N-甲基吗啉 、 盐酸 、 N,N'-羰基二咪唑 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

  摘要：

  We have synthesized a series of phosphinic acids as inhibitors of a metalloprotease endothelin converting enzyme (ECE). Potent ECE inhibitors 4g and 4o were identified. These compounds are members of a novel class of ECE inhibitors that are also potent inhibitors of angiotensin converting enzyme and neutral endopeptidase. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00297-1
• 作为产物：
  描述：

  t-Butyl 1-(Hydroxymethyl)cyclopentanecarboxylate 在 sodium hydride 作用下， 以 四氢呋喃 、 吡啶 、 二氯甲烷 为溶剂， 生成 1-[(Benzyloxycarbonylamino-methyl)-methoxy-phosphinoylmethyl]-cyclopentanecarboxylic acid tert-butyl ester
  参考文献：
  名称：

  Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

  摘要：

  We have synthesized a series of phosphinic acids as inhibitors of a metalloprotease endothelin converting enzyme (ECE). Potent ECE inhibitors 4g and 4o were identified. These compounds are members of a novel class of ECE inhibitors that are also potent inhibitors of angiotensin converting enzyme and neutral endopeptidase. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00297-1