2-(6'-iodohexyl)furan | 1101052-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(6'-iodohexyl)furan
• CAS: 1101052-84-9
• 化学式: C₁₀H₁₅IO
• 分子量: 278.133
• InChiKey: KURJSWOJQXSRMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  12.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  13.14
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-(6'-iodohexyl)furan 、 potassium phtalimide 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Sequence selective formation of 1,N6-ethenoadenine in DNA by furan-conjugated probe

  摘要：

  1,N-6-Ethenoadenosine derivatives have been applied as fluorescence probes in various fields of biochemistry and molecular biology. We developed a 1, N-6-ethenoadenosine-forming reaction at a target adenine in DNA duplex and applied it to a mutation diagnosis. Furan-derivatized oligodeoxyribonucleotides were synthesized and fluorescence properties were studied in the presence of complementary strand under oxidative conditions. Strong emissions at 430 nm were observed in the presence of the complementary strand with an adenine in front of furan moiety. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.092
• 作为产物：
  描述：

  呋喃 、 1,6-二碘己烷 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.33h， 生成 2-(6'-iodohexyl)furan
  参考文献：
  名称：

  Sequence selective formation of 1,N6-ethenoadenine in DNA by furan-conjugated probe

  摘要：

  1,N-6-Ethenoadenosine derivatives have been applied as fluorescence probes in various fields of biochemistry and molecular biology. We developed a 1, N-6-ethenoadenosine-forming reaction at a target adenine in DNA duplex and applied it to a mutation diagnosis. Furan-derivatized oligodeoxyribonucleotides were synthesized and fluorescence properties were studied in the presence of complementary strand under oxidative conditions. Strong emissions at 430 nm were observed in the presence of the complementary strand with an adenine in front of furan moiety. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.092