4-methyl-1-[5-(4-methoxyphenyl)-isoxazol-3-yl]-piperidine | 1130365-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methyl-1-[5-(4-methoxyphenyl)-isoxazol-3-yl]-piperidine
• 英文别名: 5-(4-Methoxyphenyl)-3-(4-methylpiperidin-1-yl)-1,2-oxazole；5-(4-methoxyphenyl)-3-(4-methylpiperidin-1-yl)-1,2-oxazole
• CAS: 1130365-83-1
• 化学式: C₁₆H₂₀N₂O₂
• 分子量: 272.347
• InChiKey: VWVJTZFFAGUUFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-[5-(4-methoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-4-methyl-piperidine 在 咪唑 、 碘 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以84%的产率得到4-methyl-1-[5-(4-methoxyphenyl)-isoxazol-3-yl]-piperidine
  参考文献：
  名称：

  Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines

  摘要：

  A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles Is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.

  DOI：

  10.1021/ol9000284

文献信息

• Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines
  作者：Mélina Girardin、Pamela G. Alsabeh、Sophie Lauzon、Sarah J. Dolman、Stéphane G. Ouellet、Greg Hughes

  DOI：10.1021/ol9000284

  日期：2009.3.5

  A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles Is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.