2-amino-5-(3-nitrophenyl)pyrrole-3-carboxamide | 1052080-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-amino-5-(3-nitrophenyl)pyrrole-3-carboxamide
• 英文别名: 2-amino-5-(3-nitrophenyl)-1H-pyrrole-3-carboxamide
• CAS: 1052080-59-7
• 化学式: C₁₁H₁₀N₄O₃
• 分子量: 246.225
• InChiKey: UYQXMVYMLIATPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NOVEL PYRROLE DERIVATIVE HAVING UREIDO GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS
  申请人：Kawashima Kenji

  公开号：US20100099675A1

  公开（公告）日：2010-04-22

  Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R 1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R 2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

  本发明的目的是研究合成一种具有脲基和氨基甲酰基基团或其盐的新型吡咯衍生物，发现该衍生物或其盐的药理作用，并通过口服寻找具有预防和/或治疗视网膜疾病或类似疾病的药物。通式（1）表示的化合物或其盐具有抑制白细胞介素-6的产生和/或抑制脉络膜新生血管形成的活性，因此可用作预防和/或治疗与白细胞介素-6有关的疾病、眼部炎症性疾病和/或视网膜疾病的药物。在该式中，环A表示苯环或类似物；R1表示卤素原子、氢原子、低碳基或类似物；R2表示卤素原子、可带取代基的低碳基、低烯基、可带取代基的低炔基、低环烷基、芳基、羟基、可带取代基的低烷氧基或类似物；n表示0、1、2、3或类似物。
• NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2116530A1

  公开（公告）日：2009-11-11

  Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

  本发明的目的是研究具有脲基和氨基羰基作为取代基的新型吡咯衍生物或其盐的合成，找到该衍生物或其盐的药理作用，并找到一种通过口服对视网膜疾病或类似疾病具有预防和/或治疗作用的药剂。通式（1）代表的化合物或其盐具有抑制白细胞介素-6 生成的活性和/或对脉络膜新生血管的抑制作用，因此可作为白细胞介素-6 相关疾病、眼部炎症性疾病和/或视网膜疾病的预防和/或治疗药物。在式中，环 A 代表苯环或类似物；R1 代表卤素原子、氢原子、低级烷基或类似物；R2 代表卤素原子、可能具有取代基的低级烷基、低级烯基、可能具有取代基的低级炔基、低级环烷基、芳基、羟基、可能具有取代基的低级烷氧基或类似物；n 代表 0、1、2、3 或类似物。
• US7977371B2
  申请人：——

  公开号：US7977371B2

  公开（公告）日：2011-07-12