4-(3,4-diacetoxy-benzyl)-oxazolidine-2,5-dione | 107920-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-(3,4-diacetoxy-benzyl)-oxazolidine-2,5-dione
• 英文别名: 4-(3,4-Diacetoxy-benzyl)-oxazolidin-2,5-dion；[2-Acetyloxy-4-[(2,5-dioxo-1,3-oxazolidin-4-yl)methyl]phenyl] acetate
• CAS: 107920-84-3
• 化学式: C₁₄H₁₃NO₇
• 分子量: 307.26
• InChiKey: YEQHDJHRJHSZHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三光气 、 chlorhydrate de (di-O-acetyl-3,4 phenyl)-3 alanine 以 四氢呋喃 为溶剂， 以65%的产率得到4-(3,4-diacetoxy-benzyl)-oxazolidine-2,5-dione
  参考文献：
  名称：

  贻贝粘附蛋白启发的多重相互作用配体：高度稳定和生物相容性纳米粒子的合成。

  摘要：

  全部结合：基于聚（L -3,4-二羟基苯丙氨酸）的配体通过几种结合模式将疏水性纳米颗粒转变为亲水性和生物相容性物种。用这种配体官能化的纳米颗粒（参见图片）在各种水溶液中具有很高的稳定性。使用功能化的Fe 3 O 4纳米粒子的成功的体内MRI应用证实了它们适用于各种生物医学应用。

  DOI：

  10.1002/anie.201101521

文献信息

• MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR IMAGING LYMPH NODE USING THE SAME
  申请人：Park Ju Young

  公开号：US20140023594A1

  公开（公告）日：2014-01-23

  Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.

  提供了一种用于对比成像淋巴结的对比剂，其中包括铁氧化物纳米颗粒，通过贻贝黏附蛋白类似共聚物在水介质中分散和稳定，一种利用上述对比剂进行增强淋巴造影的方法，以及一种利用上述对比剂进行淋巴结癌症诊断的方法。使用这种贻贝黏附蛋白类似共聚物，修饰了铁氧化物的表面并在水中良好分散，制备出胶体溶液，进而形成含有胶体溶液的对比剂。这种创新的对比剂无毒性，并且容易被淋巴结吸收，表现出优秀的对比成像效果。本发明的对比剂对于转移性癌症的诊断是有用的。
• Biocompatible agent for dispersing nanoparticles into an aqueous medium using mussel adhesive protein-mimetic polymer
  申请人：Hyeon Taeghwan

  公开号：US09169355B2

  公开（公告）日：2015-10-27

  Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.

  提供了一种贻贝粘附蛋白类似物分散稳定剂，用于在水性介质中分散纳米颗粒，包括由分散稳定剂分散和稳定的纳米颗粒的胶体溶液，以及包括该胶体溶液的造影剂。更具体地说，贻贝粘附蛋白类似物分散稳定剂是聚乙烯亚胺-嫁接-(聚乙二醇；聚多巴胺) PEI-嫁接-(PEG；PDOPA)。嫁接聚合物由两部分组成。一部分是聚乙二醇，嫁接有对水性介质具有亲和性的聚乙烯亚胺，另一部分是对纳米颗粒表面具有亲和性的聚多巴胺。由于这些特性，该稳定剂在水性介质中显示出纳米颗粒的稳定分散。
• Biocompatible Agent for Dispersing Nanoparticles into an Aqueous Medium Using Mussel Adhesive Protein-Mimetic Polymer
  申请人：Hyeon Taeghwan

  公开号：US20130272965A1

  公开（公告）日：2013-10-17

  Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
• US8906346B2
  申请人：——

  公开号：US8906346B2

  公开（公告）日：2014-12-09
• US9169355B2
  申请人：——

  公开号：US9169355B2

  公开（公告）日：2015-10-27