4-(2-甲基苯氧基)哌啶盐酸盐

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(2-甲基苯氧基)哌啶盐酸盐
• 英文名称: 4-(2-methylphenoxy)piperidine hydrochloride
• 英文别名: 4-(o-tolyloxy)piperidine hydrochloride；hydron;4-(2-methylphenoxy)piperidine;chloride
• 化学式: C₁₂H₁₇NO*ClH
• 分子量: 227.734
• InChiKey: BOSORTWFNPGKCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-甲基苯氧基)哌啶盐酸盐 、 5-异硫代氰酰基-2-甲氧基吡啶 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以85%的产率得到N-(6-methoxypyridin-3-yl)-4-(2-methylphenoxy)piperidine-1-thiocarboxamide
  参考文献：
  名称：

  Substituted triazole derivatives as oxytocin antagonists

  摘要：

  本发明涉及公式（I）的取代三唑化合物，其用途，制备方法以及含有该化合物的组合物。这些抑制剂在包括性功能障碍在内的各种治疗领域具有用途。

  公开号：

  US20060160786A1
• 作为产物：
  描述：

  N-Boc-4-羟基哌啶 在 盐酸 、 偶氮二甲酸二叔丁酯 、 三苯基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 2.5h， 生成 4-(2-甲基苯氧基)哌啶盐酸盐
  参考文献：
  名称：

  Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

  摘要：

  Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin deficiency-induced and diet-induced obesity, with greater whole body insulin sensitivity than wild-type animals. In this work, we have discovered a series of potent, selective, orally bioavailable SCD1 inhibitors based on a known pyridazine carboxamide template. The representative lead inhibitor 28c also demonstrates excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells.

  DOI：

  10.1021/jm070219p

文献信息

• Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders
  申请人：Collantes Elizabeth Martha

  公开号：US20090197859A1

  公开（公告）日：2009-08-06

  The present invention relates to novel pyridinyl derivatives of Formula wherein Y, Z, L, R 1 through R 11 , n, m, p, q, t are as defined herein, that are 5-HT receptor ligands, particularly the 5-HT6 subtype, and as such are useful for treating diseases wherein modulation of 5-HT activity is desired. The present invention relates to novel pyridinyl derivatives including their pharmaceutically acceptable salts. The invention also relates to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing and the uses of such compounds in treating diseases of the central nervous system such as schizophrenia.

  本发明涉及一种新颖的吡啶基衍生物，其化学式如下所示：其中Y、Z、L、R1至R11、n、m、p、q、t的定义如本文所述，它们是5-HT受体配体，特别是5-HT6亚型，因此可用于治疗需要调节5-HT活性的疾病。本发明涉及包括其药用盐在内的新型吡啶基衍生物。该发明还涉及用于制备、制备中间体、含有这些化合物的药物组合物以及在治疗中枢神经系统疾病如精神分裂症中使用这些化合物的过程。
• [EN] NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS ARYLOXYPIPÉRIDINE PYRAZOLE UTILES EN TANT QU'INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2020041100A1

  公开（公告）日：2020-02-27

  Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

  本文介绍了一种公式（I）的化合物，这些化合物是IDO酶的抑制剂：本文还披露了这些化合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。本文还披露了包含这些化合物的组合物。本文还披露了这些组合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。
• Substituted Triazole Derivatives As Oxytocin Antagonists
  申请人：Brown Alan Daniel

  公开号：US20090253674A1

  公开（公告）日：2009-10-08

  The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.

  本发明涉及公式(I)的取代三唑，其用途、制备过程和含有该化合物的组合物。这些抑制剂在包括性功能障碍在内的多种治疗领域中具有实用性。
• SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS
  申请人：Ixchelsis Limited

  公开号：US20150322042A1

  公开（公告）日：2015-11-12

  The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.

  本发明涉及式(I)的取代三唑，以及其用途、制备过程和含有该化合物的组合物。这些抑制剂在包括性功能障碍在内的各种治疗领域中具有实用性。
• WO2020154571A5
  申请人：——

  公开号：WO2020154571A5

  公开（公告）日：2023-02-02