2-[diethoxy(oxido)phosphaniumyl]-3,5-diphenyl-1H-pyrrole | 1526987-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[diethoxy(oxido)phosphaniumyl]-3,5-diphenyl-1H-pyrrole
• CAS: 1526987-44-9
• 化学式: C₂₀H₂₂NO₃P
• 分子量: 355.373
• InChiKey: MUAJGZSGNOECNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二苯基吡咯 、 亚磷酸二乙酯 在 dipotassium peroxodisulfate 、 silver nitrate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以68%的产率得到2-[diethoxy(oxido)phosphaniumyl]-3,5-diphenyl-1H-pyrrole
  参考文献：
  名称：

  An expedient synthesis of pyrrole-2-phosphonates via direct oxidative phosphorylation and γ-hydroxy-γ-butyrolactams from pyrroles

  摘要：

  An expedient oxidative phosphorylation of pyrroles has been disclosed. The reaction of dialkyl phosphite and pyrrole in the presence of AgNO3/K2S2O8 in DMF/H2O (8:1) produced pyrrole-2-phosphonates in good yields. In the absence of dialkyl phosphite, gamma-hydroxy-gamma-butyrolactam derivative was formed as a major product. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.11.082

文献信息

• An expedient synthesis of pyrrole-2-phosphonates via direct oxidative phosphorylation and γ-hydroxy-γ-butyrolactams from pyrroles
  作者：Se Hee Kim、Ko Hoon Kim、Jin Woo Lim、Jae Nyoung Kim

  DOI：10.1016/j.tetlet.2013.11.082

  日期：2014.1

  An expedient oxidative phosphorylation of pyrroles has been disclosed. The reaction of dialkyl phosphite and pyrrole in the presence of AgNO3/K2S2O8 in DMF/H2O (8:1) produced pyrrole-2-phosphonates in good yields. In the absence of dialkyl phosphite, gamma-hydroxy-gamma-butyrolactam derivative was formed as a major product. (C) 2013 Elsevier Ltd. All rights reserved.