4-azido-1-bromo-2-(chloromethyl)benzene | 941703-21-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-azido-1-bromo-2-(chloromethyl)benzene
• CAS: 941703-21-5
• 化学式: C₇H₅BrClN₃
• 分子量: 246.494
• InChiKey: KBSDUOCCHVVIEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-azido-1-bromo-2-(chloromethyl)benzene 在 sodium carbonate 、 sodium iodide 作用下， 以 丙酮 、 乙腈 为溶剂， 反应 28.0h， 生成 N,N-bis[(5-azido-2-bromophenyl)methyl]-1-(3-azidophenyl)ethanamine
  参考文献：
  名称：

  Center-to-propeller and propeller-to-propeller stereocontrol in a series of macrobicyclic tri-λ5-phosphazenes

  摘要：

  Center-to-propeller stereocontrol in a family of macrobicyclic, double-propeller shaped tri-lambda(5)-triphosphazenes remains constant in the upper tribenzylamine fragment as the size of the pivotal group at the lower tris(phosphane) fragment is gradually increased. In contrast the propeller-to-propeller stereocontrol diminishes as a result of the increasing conformational lability in the lower hemisphere. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.087
• 作为产物：
  描述：

  5-azido-2-bromobenzyl alcohol 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以44%的产率得到4-azido-1-bromo-2-(chloromethyl)benzene
  参考文献：
  名称：

  Center-to-propeller and propeller-to-propeller stereocontrol in a series of macrobicyclic tri-λ5-phosphazenes

  摘要：

  Center-to-propeller stereocontrol in a family of macrobicyclic, double-propeller shaped tri-lambda(5)-triphosphazenes remains constant in the upper tribenzylamine fragment as the size of the pivotal group at the lower tris(phosphane) fragment is gradually increased. In contrast the propeller-to-propeller stereocontrol diminishes as a result of the increasing conformational lability in the lower hemisphere. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.087