-glycin | 52071-01-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: -glycin
• 英文别名: 3,4,5-Trimethoxybenzoylglycylglycine；2-[[2-[(3,4,5-trimethoxybenzoyl)amino]acetyl]amino]acetic acid
• CAS: 52071-01-9
• 化学式: C₁₄H₁₈N₂O₇
• 分子量: 326.306
• InChiKey: ANGXQICJCYNPMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,4'-二氨基二苯醚 、 -glycin 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 以69%的产率得到3,4,5-trimethoxy-N-[2-oxo-2-[[2-oxo-2-[4-[3-[[2-[[2-[(3,4,5-trimethoxybenzoyl)amino]acetyl]amino]acetyl]amino]phenoxy]anilino]ethyl]amino]ethyl]benzamide
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ1–40 aggregation in vitro

  摘要：

  A series of N-terminus benzamides of glycine-based symmetric peptides, linked to m-xylylenediamine and 3,4'-oxydianiline spacers, were prepared and tested as inhibitors of beta-amyloid peptide A beta(1 - 40) aggregation in vitro. Compounds with good anti-aggregating activity were detected. Polyphenolic amides showed the highest anti-aggregating activity, with IC50 values in the micromolar range. Structure - activity relationships suggested that pi - pi stacking and hydrogen-bonding interactions play a key role in the inhibition of A beta(1 - 40) self-assembly leading to amyloid fibrils. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.052