2-[6-[2-[9-(2-Aminoethyl)purin-8-yl]ethynyl]purin-9-yl]ethanamine | 1426313-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[6-[2-[9-(2-Aminoethyl)purin-8-yl]ethynyl]purin-9-yl]ethanamine
• 英文别名: 2-[6-[2-[9-(2-aminoethyl)purin-8-yl]ethynyl]purin-9-yl]ethanamine
• CAS: 1426313-61-2
• 化学式: C₁₆H₁₆N₁₀
• 分子量: 348.37
• InChiKey: SPIYAWDSYNHMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-(adenin-9-yl)-N-<(tert-butyloxy)carbonyl>ethylamine 在 四氢呋喃 、 copper(l) iodide 、 四(三苯基膦)钯 、 亚硝酸正戊酯 、 四丁基氟化铵 、 溴 、 sodium acetate 、 四氯化锡 、 caesium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 水 、 乙酸乙酯 为溶剂， 反应 13.5h， 生成 2-[6-[2-[9-(2-Aminoethyl)purin-8-yl]ethynyl]purin-9-yl]ethanamine
  参考文献：
  名称：

  乙炔桥 6,8-嘌呤二聚体作为平行 G-四链体的荧光开关探针

  摘要：

  点亮：报道了由两个乙炔桥嘌呤组成的 G 四联体荧光探针（APD）的系统设计和合成。APD 在平行 DNA（例如 c-MYC）或 RNA G-四链体存在时亮起，而双链 DNA、反平行或混合型（例如 h-Telo）G-四链体则没有荧光增强（参见图片）。还证明了 APD 在 G-四链体优先染色中的实用性。

  DOI：

  10.1002/anie.201207075

文献信息

• Method for detecting target molecule in which rolling circle amplification is used
  申请人：National University Corporation Gunma University

  公开号：US11359240B2

  公开（公告）日：2022-06-14

  A method of detecting a target molecule, the method comprising: forming a complex of a target molecule, a capture oligonucleotide, an oligonucleotide primer, and a single-stranded circular DNA; performing a nucleic acid amplification reaction by rolling circle amplification based on the formation of the complex; and detecting amplified nucleic acid; wherein the single-stranded circular DNA contains a first region, and a second region linked to the 3′-side of the first region, and preferably further contains a sequence complementary to a detection reagent-binding sequence; the primer contains a first aptamer sequence which binds to the target molecule, and a sequence which is linked to the 3′-side of the first aptamer sequence and is complementary to the first region of the single-stranded circular DNA; and the capture oligonucleotide contains a sequence complementary to the second region of the single-stranded circular DNA, and a second aptamer sequence which is linked to the 3′-side of the sequence complementary to the second region and binds to the target molecule.

  一种检测目标分子的方法，该方法包括形成目标分子、捕获寡核苷酸、寡核苷酸引物和单链环状 DNA 的复合物；根据复合物的形成，通过滚圆扩增进行核酸扩增反应；以及检测扩增的核酸；其中，单链环状 DNA 包含第一区域和与第一区域的 3′-侧相连的第二区域，并且最好进一步包含与检测试剂结合序列互补的序列；引物包含与目标分子结合的第一适配体序列，以及与第一适配体序列的 3′-侧连接并与单链环状 DNA 的第一区域互补的序列；捕获寡核苷酸包含与单链环状 DNA 第二区域互补的序列，以及与第二区域互补序列的 3′-侧相连并与靶分子结合的第二适配体序列。
• Simple Method for Detecting RNA Sequences
  申请人：National University Corporation Gunma University

  公开号：US20190040465A1

  公开（公告）日：2019-02-07

  An RNA detection kit comprising: (i) a single-stranded circular DNA template containing: a sequence of 10 to 30 bases complementary to a first portion of a target RNA; a primer-binding sequence of 7 to 8 bases adjacent to 5′-side thereof; and a sequence complementary to a detection reagent-binding sequence such as a guanine quadruplex-forming sequence; (ii) an oligonucleotide primer containing: a sequence of 8 to 15 bases complementary to a second portion adjacent to the 3′-side of the first portion of the target RNA; and a sequence of 7 to 8 bases adjacent to 3′-side thereof and complementary to the primer-binding sequence of the single-stranded circular DNA template; and (iii) a detection reagent such as a guanine quadruplex-binding reagent; is provided.
• METHOD FOR DETECTING TARGET MOLECULE IN WHICH ROLLING CIRCLE AMPLIFICATION IS USED
  申请人：National University Corporation Gunma University

  公开号：US20200071759A1

  公开（公告）日：2020-03-05

  A method of detecting a target molecule, the method comprising: forming a complex of a target molecule, a capture oligonucleotide, an oligonucleotide primer, and a single-stranded circular DNA; performing a nucleic acid amplification reaction by rolling circle amplification based on the formation of the complex; and detecting amplified nucleic acid; wherein the single-stranded circular DNA contains a first region, and a second region linked to the 3′-side of the first region, and preferably further contains a sequence complementary to a detection reagent-binding sequence; the primer contains a first aptamer sequence which binds to the target molecule, and a sequence which is linked to the 3′-side of the first aptamer sequence and is complementary to the first region of the single-stranded circular DNA; and the capture oligonucleotide contains a sequence complementary to the second region of the single-stranded circular DNA, and a second aptamer sequence which is linked to the 3′-side of the sequence complementary to the second region and binds to the target molecule.
• SIMPLE METHOD FOR DETECTING NUCLEIC ACID SEQUENCE, ETC.
  申请人：Nihon University

  公开号：US20220213525A1

  公开（公告）日：2022-07-07

  A nucleic acid detection kit including: (i) a first single-stranded circular DNA; (ii) a first oligonucleotide primer; (iii) a second single-stranded circular DNA; and (iv) a second oligonucleotide primer; wherein the first oligonucleotide primer is hound to a carrier through the 5′-end thereof, and the second oligonucleotide primer is bound, through the 5′-end thereof, to the carrier to which the first oligonucleotide primer is hound.