[4-(2-Aminoethylcarbamoyloxymethyl)-6-bromo-2-oxochromen-7-yl] octadecanoate | 1207325-88-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: [4-(2-Aminoethylcarbamoyloxymethyl)-6-bromo-2-oxochromen-7-yl] octadecanoate
• 英文别名: [4-(2-aminoethylcarbamoyloxymethyl)-6-bromo-2-oxochromen-7-yl] octadecanoate
• CAS: 1207325-88-9
• 化学式: C₃₁H₄₇BrN₂O₆
• 分子量: 623.628
• InChiKey: MRTJINJLSJRTMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  40
• 可旋转键数：
  23
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-bromo-4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundecyl)-2-oxo-2H-chromen-7-yl stearate 在 苯甲醚 、 三氟乙酸 作用下， 以100%的产率得到[4-(2-Aminoethylcarbamoyloxymethyl)-6-bromo-2-oxochromen-7-yl] octadecanoate
  参考文献：
  名称：

  Light-mediated and H-bond facilitated liposomal release: the role of lipid head groups in release efficiency

  摘要：

  Syntheses of coumarin-containing lipids and liposomal formulations incorporating these lipids are studied. The influence of the lipid head groups in enhancing the release efficiency of these liposomes under light irradiation is studied and a molecular mechanism is provided. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.084

文献信息

• Light-mediated and H-bond facilitated liposomal release: the role of lipid head groups in release efficiency
  作者：Rajesh Subramaniam、Ying Xiao、Yunjing Li、Steven Y. Qian、Wenfang Sun、Sanku Mallik

  DOI：10.1016/j.tetlet.2009.11.084

  日期：2010.1

  Syntheses of coumarin-containing lipids and liposomal formulations incorporating these lipids are studied. The influence of the lipid head groups in enhancing the release efficiency of these liposomes under light irradiation is studied and a molecular mechanism is provided. (C) 2009 Elsevier Ltd. All rights reserved.