1-Hydroxynon-8-en-4-one | 85362-52-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Hydroxynon-8-en-4-one
• CAS: 85362-52-3
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: YEOZGXBDKWTTBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Hydroxynon-8-en-4-one 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 methyl (2E)-6-oxoundeca-2,10-dienoate
  参考文献：
  名称：

  Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides

  摘要：

  The reactants of an anti-malarial peroxide having a 6-carbomethoxymethyl-3-methoxy-1,2-dioxane moiety treated with FeSO4 were analyzed. For mechanistic study of the anti-malarial peroxide, two biotinylated probes to elucidate the target molecules were designed and synthesized. The two synthesized probes showed potent anti-malarial activity, and one of them was proved to form an irreversible binding with protein in a model experiment. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.086
• 作为产物：
  描述：

  magnesium,pent-1-ene,bromide 在 camphor-10-sulfonic acid 、 dipyridine chromium trioxide 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 1-Hydroxynon-8-en-4-one
  参考文献：
  名称：

  Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclization reactions

  摘要：

  DOI：

  10.1016/s0040-4039(00)85671-3

文献信息

• Structure–activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure
  作者：Motoyuki Kawanishi、Naoyuki Kotoku、Sawako Itagaki、Toshihiro Horii、Motomasa Kobayashi

  DOI：10.1016/j.bmc.2004.04.051

  日期：2004.10

  In order to study the structure-activity relationship of anti-malarial spongean peroxides, several analogues concerning with the 6-methoxyacetyl moiety and the 3-pentyl residue in methyl 2-(3-methoxy-3-pentyl-1,2-dioxan-6-yl) acetate were synthesized and evaluated for anti-malarial activity. The tert-butyl ester analogue 14 showed stability in mouse serum and a high selectivity index against the malaria parasite, Plasmodium falciparum, and the citronellyl analogue 31 exhibited the strongest in vitro antimalarial activity among them, and the imidazole analogue 25 showed desirable in vivo anti-malarial activity against P. berghei infected mice. (C) 2004 Elsevier Ltd. All rights reserved.
• YADAV, J. S.;STEENIVASA, RAO E.;RAO, C. S.;CHOUDARY, B. M., J. MOL. CATAL., 49,(1989) N, C. L61-L63
  作者：YADAV, J. S.、STEENIVASA, RAO E.、RAO, C. S.、CHOUDARY, B. M.

  DOI：——

  日期：——