苯甲醇,2-硝基-a-苯基-,乙酸酯(ester) | 108621-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲醇,2-硝基-a-苯基-,乙酸酯(ester)
• 英文名称: acetic acid (2-nitro-phenyl)-phenyl-methyl ester
• 英文别名: (+/-)-acetic acid-(2-nitro-benzhydryl ester)；(+/-)-Essigsaeure-(2-nitro-benzhydrylester)；[(2-Nitrophenyl)-phenylmethyl] acetate
• CAS: 108621-64-3
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: BXEQCASVNRVWHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  407.5±30.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯甲醇,2-硝基-a-苯基-,乙酸酯(ester) 以 乙腈 为溶剂， 反应 1.17h， 生成 o-Nitroso-benzophenon 、 溶剂黄146
  参考文献：
  名称：

  Novel Photoacid Generators for Photodirected Oligonucleotide Synthesis

  摘要：

  Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5'deprotection. Both have been reported to give lower stepwise synthetic yields than conventional methods. The deficiency appears to be due to incomplete deprotection at the, oligonucleotide 5'-position and, additionally in the case where photodirection is indirect and uses photogenerated photoacid to effect 5'-detritylation, the depurinating effects of strong acid. We have developed novel photosensitive-2-nitrobenzyl esters that on irradiation with near UV light generate alpha-chloro-substituted acetic acids, such as trichloroacetic acid, which are widely and successfully used in conventional solid-phase oligonucleotide synthesis. alpha-Phenyl-4,5-dimethoxy-2-nitrobenzyltrichloroacetate and alpha-phenyl-4,5-dimethoxy-2,6-dinitrobenzyltrichloroacetate showed appropriate photochemical characteristics and were used for photodirected synthesis of a variety of oligonucleotides, including (T)(5), TATAT, TGTGT, (T)(10), (AT)(5), (CT)(5) (GT)(5), and (TGCAT)(2) on a modified Millipore Expedite DNA synthesizer. The outcomes were compared with those obtained by use of directly added trichloroacetic acid (conventional synthesis). The stepwise yields for the two methods were essentially identical.

  DOI：

  10.1021/ja017635y
• 作为产物：
  描述：

  phenylmagnesium bromide 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 8.75h， 生成 苯甲醇,2-硝基-a-苯基-,乙酸酯(ester)
  参考文献：
  名称：

  Novel Photoacid Generators for Photodirected Oligonucleotide Synthesis

  摘要：

  Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5'deprotection. Both have been reported to give lower stepwise synthetic yields than conventional methods. The deficiency appears to be due to incomplete deprotection at the, oligonucleotide 5'-position and, additionally in the case where photodirection is indirect and uses photogenerated photoacid to effect 5'-detritylation, the depurinating effects of strong acid. We have developed novel photosensitive-2-nitrobenzyl esters that on irradiation with near UV light generate alpha-chloro-substituted acetic acids, such as trichloroacetic acid, which are widely and successfully used in conventional solid-phase oligonucleotide synthesis. alpha-Phenyl-4,5-dimethoxy-2-nitrobenzyltrichloroacetate and alpha-phenyl-4,5-dimethoxy-2,6-dinitrobenzyltrichloroacetate showed appropriate photochemical characteristics and were used for photodirected synthesis of a variety of oligonucleotides, including (T)(5), TATAT, TGTGT, (T)(10), (AT)(5), (CT)(5) (GT)(5), and (TGCAT)(2) on a modified Millipore Expedite DNA synthesizer. The outcomes were compared with those obtained by use of directly added trichloroacetic acid (conventional synthesis). The stepwise yields for the two methods were essentially identical.

  DOI：

  10.1021/ja017635y

文献信息

• Photolabile esters and their uses
  申请人：——

  公开号：US20040242653A1

  公开（公告）日：2004-12-02

  Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5′-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5′-O-DMT-nucleoside-3′-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.

  本文披露了能够在光解作用下产生酸的化合物，并介绍了这些化合物的用途，特别是在合成阵列期间去保护核酸分子或肽的末端。本文所描述的化合物可用于通过光解产生能够去除DMT基团的酸来去除5'-O-二甲氧基三苯基甲酰（DMT）保护的核苷酸，从而使用常规固相核酸合成中使用的易得的5'-O-DMT-核苷酸-3'-O-磷酸酰胺单体合成寡核苷酸阵列。本文还披露了一种避免投影光刻技术中杂散光影响的方法。
• Color forming compositions and associated methods
  申请人：Bhatt Jayprakash C.

  公开号：US20070269737A1

  公开（公告）日：2007-11-22

  Compositions and methods for forming color images on a substrate capable of development at desired wavelengths or energy levels are disclosed and described. The color forming composition can include a carrier system and a latent pigment with a pendent group, wherein the latent pigment is colorless or pale in color while the pendent group is attached, and wherein the latent pigment is convertible to a colored pigment upon removal of the pendent group. Alternatively, the latent pigment can have multiple states of conjugation where the latent pigment is colorless or pale in a first conjugation state, and colored in a second conjugation state. The color forming compositions are useful in forming images on a wide variety of substrates, such as optical disks.
• US8283100B2
  申请人：——

  公开号：US8283100B2

  公开（公告）日：2012-10-09
• [EN] COLOR FORMING COMPOSITIONS AND ASSOCIATED METHODS<br/>[FR] COMPOSITIONS POUR LA FORMATION DE COULEURS ET PROCÉDÉS ASSOCIÉS
  申请人：HEWLETT PACKARD DEVELOPMENT CO

  公开号：WO2007136997A2

  公开（公告）日：2007-11-29

  [EN] Compositions and methods for forming color images on a substrate capable of development at desired wavelengths or energy levels are disclosed and described. The color forming composition can include a carrier system and a latent pigment with a pendent group, wherein the latent pigment is colorless or pale in color while the pendent group is attached, and wherein the latent pigment is convertible to a colored pigment upon removal of the pendent group. Alternatively, the latent pigment can have multiple states of conjugation where the latent pigment is colorless or pale in a first conjugation state, and colored in a second conjugation state. The color forming compositions are useful in forming images on a wide variety of substrates, such as optical disks.
  [FR] La présente invention concerne des compositions et des procédés de formation d'images en couleur sur un substrat capable de développement à des longueurs d'ondes ou des niveaux d'énergie souhaités. Ces compositions de formation de couleurs peuvent comporter un système vecteur et un pigment latent avec un groupe en attente, le pigment latent étant incolore ou de couleur pâle alors que le groupe en attente est attaché, et le pigment latent est convertible en pigment coloré à l'élimination du groupe en attente. Selon un autre mode de réalisation, le pigment latent peut connaître plusieurs états de conjugaison faisant que le pigment latent est incolore ou pâle à un premier état de conjugaison, et coloré à un deuxième état de conjugaison. Ces compositions de formation des couleurs conviennent particulièrement à la formation d'images sur une grande diversité de substrats tels que les disques optiques.