diethyl 4-bromo-3-methylbenzylphosphonate | 1443644-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 4-bromo-3-methylbenzylphosphonate
• 英文别名: 1-bromo-4-(diethoxyphosphorylmethyl)-2-methylbenzene
• CAS: 1443644-64-1
• 化学式: C₁₂H₁₈BrO₃P
• 分子量: 321.151
• InChiKey: WRYWFKGVEDBACL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.52
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  四(三苯基膦)镍 、 diethyl 4-bromo-3-methylbenzylphosphonate 以 甲苯 为溶剂， 以29%的产率得到(4-((diethoxyphosphoryl)methyl)-2-methylphenyl)bis(triphenyl-l5-phosphaneyl)nickel(IV) bromide
  参考文献：
  名称：

  Synthesis of End-Group Functionalized P3HT: General Protocol for P3HT/Nanoparticle Hybrids

  摘要：

  Poly(3-hexylthiophene)s were synthesized with phosphonic ester, pyridine, thiol, and phenol end-groups using functionalized air-stable Ni initiators. The protected thiol- and phenol-functionalized P3HTs were converted into thiol and phenol P3HTs by quantitative postpolymerization reactions. H-1 NMR and MALDI-ToF analysis showed very high degrees of functionalization and strong control over the polymerization except for the pyridine functionalized P3HT. These functional end-groups were used to prepare hybrid materials from a broad variety of nanoparticles, including metal oxides, quantum dots, and noble metals.

  DOI：

  10.1021/ma401809e
• 作为产物：
  描述：

  4-溴-3-甲基苄醇 在 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 32.0h， 生成 diethyl 4-bromo-3-methylbenzylphosphonate
  参考文献：
  名称：

  Synthesis of End-Group Functionalized P3HT: General Protocol for P3HT/Nanoparticle Hybrids

  摘要：

  Poly(3-hexylthiophene)s were synthesized with phosphonic ester, pyridine, thiol, and phenol end-groups using functionalized air-stable Ni initiators. The protected thiol- and phenol-functionalized P3HTs were converted into thiol and phenol P3HTs by quantitative postpolymerization reactions. H-1 NMR and MALDI-ToF analysis showed very high degrees of functionalization and strong control over the polymerization except for the pyridine functionalized P3HT. These functional end-groups were used to prepare hybrid materials from a broad variety of nanoparticles, including metal oxides, quantum dots, and noble metals.

  DOI：

  10.1021/ma401809e

文献信息

• CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20220089538A1

  公开（公告）日：2022-03-24

  Compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to depression, major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder), cancers and eye conditions: wherein R 1 , , R 3 , and L are as defined herein.

  式(I)的化合物及其药用盐、同位素、N-氧化物、溶剂合物和立体异构体，包含它们的药物组合物，制备它们的方法以及使用它们的方法，包括用于治疗与MGL调节相关的疾病状态、疾病和症状的方法，如与疼痛、精神障碍、神经障碍（包括但不限于抑郁症、重度抑郁症、治疗抵抗性抑郁症、焦虑性抑郁症、自闭症谱系障碍、阿斯伯格综合征和躁狂症）、癌症和眼部疾病相关的疾病状态、疾病和症状：其中R1、R3和L如本文所定义。