N-[[1-(3-methoxypropyl)indol-3-yl]methyl]ethanamine | 916337-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[[1-(3-methoxypropyl)indol-3-yl]methyl]ethanamine
• CAS: 916337-59-2
• 化学式: C₁₅H₂₂N₂O
• mdl: MFCD20173750
• 分子量: 246.352
• InChiKey: UDMDOPYHQRCVHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.466
• 拓扑面积：
  26.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Organic Compounds
  申请人：Nihonyanagi Atsuko

  公开号：US20080242662A1

  公开（公告）日：2008-10-02

  The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula I, wherein R1, R2, R11, C, E and D are as defined in the specification.

  本发明涉及取代的3,4-或更高取代的哌嗪化合物，其用于制备治疗依赖于肾素活性的疾病的药物配方；该类化合物在治疗依赖于肾素活性的疾病中的应用；这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=紊乱）；包括上述化合物和/或其制剂的制药制剂或产品，以及包括给予上述化合物的治疗方法，制造上述化合物的方法以及新的中间体，起始材料和/或其合成的部分步骤。这些化合物特别是公式I，其中R1、R2、R11、C、E和D如规范中所定义。