(1R,2R,3S,6R,7S)-1,8,9,10,11,11-hexachlorotetracyclo[6.2.1.13,6.02,7]dodeca-4,9-diene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: (1R,2R,3S,6R,7S)-1,8,9,10,11,11-hexachlorotetracyclo[6.2.1.13,6.02,7]dodeca-4,9-diene
• 化学式: C₁₂H₈Cl₆
• 分子量: 364.9
• InChiKey: QBYJBZPUGVGKQQ-HSECHKQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

当异狄林与来自切除的菜豆幼苗（Phaseolus vulgaris）根部的匀浆一起孵化时...观察到与狄林酮（delta-酮狄林）相对应的色谱化合物。第二种代谢物以非常小的量存在，观察到但未鉴定。没有发现狄林。

When isodrin was incubated with homogenates from excised roots of bean seedlings (phaseolus vulgaris) ... cmpd corresponding chromatographically to endrin ketone (delta-keto endrin) was observed. A second metabolite, present in very small amt, observed, but not identified. No endrin was found.

来源:Hazardous Substances Data Bank (HSDB)

代谢

...异狄氏剂...通过兔肝微粒体转化为狄氏剂。显然，这个酶系统不会对产物狄氏剂进行进一步代谢。

... Isodrin ... is converted to endrin by rabbit liver microsomes. Apparently no further metabolism of the product endrin occurs with this enzyme system.

来源:Hazardous Substances Data Bank (HSDB)

代谢

已证明在易感型和抗性家蝇品系中，异狄氏剂向恩氏剂的转化... 易感和抗性蝇在局部施用异狄氏剂和恩氏剂后，体内含有少量（施用剂量的3-4%）水溶性物质，这种物质似乎与半笼状酮衍生物相同.../这是/已知的恩氏剂重排产物。

Conversion of isodrin to endrin ... has been demonstrated in both susceptible & resistant strains of houseflies. ... Susceptible & resistant flies topically treated with isodrin & endrin contained small ... amt (3-4% of applied dose) of water sol substance that appeared to be identical to the semi-caged keto derivative ... /which is/ known rearrangement product of endrin.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在将14C标记的异狄林（1毫克/株）施用到幼嫩白菜叶片后，4周内在植物和土壤中回收了44%的施用放射性，10周后回收了37%。10周后，只有异狄林的转化产物作为残留物被检测到。在将14C异狄林施用到土壤中（0.19 ppm）后，胡萝卜在4周后仅含有3.1%的施用放射性，12周后含有4.0%。在这两个实验中，恩德林和 delta-酮恩德林被识别为异狄林的转化产物。

After application of (14)C labeled isodrin (1 mg/plant) to leaves of young white cabbage, 44% of the applied radioactivity was recovered in the plants & soil after 4 wk, & 37% after 10 wk. After 10 wk only conversion products of isodrin were detectable as residues. After application of (14)C isodrin to soil (0.19 ppm), carrots contained only 3.1% of the applied radioactivity after 4 wk & 4.0% after 12 wk. In both experiments, endrin and delta ketoendrin were identified as conversion products of isodrin.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

家蝇将异菌转化为恩菌。芝麻提取物起到增效作用。

Houseflies metabolized isodrin to endrin. Sesamex acted as a synergist.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。必要时进行吸痰。观察呼吸不足的迹象，并在必要时协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。预期可能出现癫痫，减少所有外部刺激，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……。/艾氏剂、狄氏剂、恩氏剂及有关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures, reduce all external stimuli, and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aldrin, dieldrin, endrin, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常。开始静脉输注D5W/SRP：“保持通路开放”，最低流速。如果出现低血容量的迹象，使用0.9%盐水（NS）或乳酸林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。用地西泮或劳拉西泮治疗癫痫。使用丙美卡因，盐酸以协助眼部冲洗。/艾氏剂、狄氏剂、恩氏剂及相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... Treat seizures with diazepam or lorazepam ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Aldrin, dieldrin, endrin, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

观察。任何途径接触高浓度有机氯杀虫剂的人员应被监测是否有感觉异常、动作不协调、言语不清、精神异常和不自主的肌肉活动，这些症状可能预示即将发生抽搐。/固体有机氯杀虫剂/

Observation. Persons exposed to high levels of organochlorine pesticides by any route should be observed for sensory disturbances, incoordination, speech slurring, mental aberrations, and involuntary motor activity that would warn of imminent convulsions. /Solid organochlorine insecticides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

抽搐。如果发生抽搐，将受害者置于左侧卧位，头部向下。移开可能造成伤害的家具或其他固体物品。...尽可能的情况下，取出假牙和其他可移动的牙齿修复物。吸除口腔和咽喉分泌物，并在可能的情况下，插入口咽通气管以保持呼吸道畅通，不受舌头阻塞。尽量减少噪音和任何可能触发癫痫活动的患者操作。由有机氯中毒引起的患者癫痫发作可能会持续较长时间且难以控制。癫痫持续状态很常见。...应首先使用苯二氮卓类药物进行治疗。/固体有机氯杀虫剂/

Convulsions. If convulsions occur, place the victim in the left lateral decubitus position with the head down. Move away furniture or other solid objects that could be a source of injury. ... Whenever possible, remove dentures and other removable dental work. Aspirate oral and pharyngeal secretions, and, when possible, insert an oropharyngeal airway to maintain an open passage unobstructed by the tongue. Minimize noise and any manipulation of the patient that may trigger seizure activity. Seizures in patients caused by organochlorine toxicity are likely to be prolonged and difficult to control. Status epilepticus is common. ... Initial therapy with benzodiazepines should be instituted. /Solid organochlorine insecticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

从哺乳动物研究中发现，与阿德灵和狄尔德林相比，异德灵和恩德灵中未氯化降冰片烯核的倒置使这个环在体内暴露于酶促羟基化，并显著增加了这些化合物从哺乳动物组织中消除的速率，这与它们在昆虫组织中的行为形成对比。

... From mammalian studies that the inversion of the unchlorinated norbornene nucleus in isodrin and endrin (as compared with aldrin and dieldrin) exposes this ring to enzymatic hydroxylation in vivo and greatly incr the rate of elimination of these cmpd from mammalian tissues, in contrast to their behavior in insect tissues.

来源:Hazardous Substances Data Bank (HSDB)