4-(3,4-二氟苯氧基)哌啶盐酸盐 | 1051919-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(3,4-二氟苯氧基)哌啶盐酸盐
• 英文名称: 4-(3,4-difluorophenoxy)piperidine hydrochloride
• 英文别名: 4-(3,4-difluorophenoxy)piperidine;hydrochloride
• CAS: 1051919-38-0
• 化学式: C₁₁H₁₃F₂NO*ClH
• 分子量: 249.688
• InChiKey: IHYVWAGJHCWHIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-Boc-L-缬氨酸 、 4-(3,4-二氟苯氧基)哌啶盐酸盐 生成 t-butyl [(1S)-1-{[4-(3,4-difluorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]carbamate
  参考文献：
  名称：

  EP2258697

  摘要：

  公开号：

文献信息

• HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE
  申请人：Motoki Kayoko

  公开号：US20110053933A1

  公开（公告）日：2011-03-03

  The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R 1 and R 2 independently represents a group such as a hydrogen atom or a halogen atom; R 3 represents a group such as a hydrogen atom; each of R 4 and R 5 independently represents a group such as a hydrogen atom, a halogen atom or a C 1-4 alkyl group; each of R 6 and R 7 independently represents a hydrogen atom or a C 1-4 alkyl group; X represents a group such as a C 3-10 cycloalkyl group, C 6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as —CO—, —O— or —NRa—, and Ra represents a group such as a hydrogen atom or a C 1-4 alkyl group.

  本发明提供了一种新型的羟基喹喔啉羧酰胺衍生物，可用于预防和/或治疗血液凝固障碍。该化合物由式(i)表示，或其药学上可接受的盐：其中，R1和R2各自独立地表示氢原子或卤素原子等基团；R3表示氢原子等基团；R4和R5各自独立地表示氢原子、卤素原子或C1-4烷基等基团；R6和R7各自独立地表示氢原子或C1-4烷基等基团；X表示C3-10环烷基、C6-10芳基或5-至10元杂环基等基团，该基团可以被选自取代基团α的取代基团所取代；Y表示—CO—、—O—或—NRa—等基团，其中Ra表示氢原子或C1-4烷基等基团。
• SUBSTITUTED N-[2-(4-PHENOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE AND N-[2-(4-BENZYLOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR ANTAGONIST
  申请人：AXXAM S.p.A.

  公开号：EP3290416A1

  公开（公告）日：2018-03-07

  The present invention relates to novel substituted phenoxy- and benzyloxy-piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.

  本发明涉及具有 P2X7 受体（P2X7）拮抗特性的式 (I) 的新型取代苯氧基和苄氧基哌啶化合物、包含这些化合物的药物组合物、制备这些化合物的化学工艺及其在治疗或预防动物，特别是人类与 P2X7 受体活性相关疾病中的用途。
• Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
  申请人：Axxam S.P.A.

  公开号：US10669267B2

  公开（公告）日：2020-06-02

  The present invention relates to novel substituted phenoxy- and benzyloxy-piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.

  本发明涉及具有 P2X7 受体（P2X7）拮抗特性的式 (I) 的新型取代苯氧基和苄氧基哌啶化合物、包含这些化合物的药物组合物、制备这些化合物的化学工艺及其在治疗或预防动物，特别是人类与 P2X7 受体活性相关疾病中的用途。
• SUBSTITUTED N-[2-(4-PHENOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE AND N-[2-(4-BENZYLOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE DERIVATIVES P2X7 RECEPTOR ANTAGONISTS
  申请人：AXXAM S.p.A.

  公开号：EP3507287B1

  公开（公告）日：2020-07-15
• EP2258697
  申请人：——

  公开号：——

  公开（公告）日：——