5-hydroxy-5-(2-oxo-4-(phenylamino)-2,5-dihydrofuran-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | 1414774-58-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-hydroxy-5-(2-oxo-4-(phenylamino)-2,5-dihydrofuran-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS: 1414774-58-5
• 化学式: C₁₄H₁₁N₃O₆
• 分子量: 317.258
• InChiKey: DSLHCGOQCDHHAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.99
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  133.83
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  5,5-二羟基六氢嘧啶-2,4,6-三酮 、 4-苯胺基呋喃-2(5H)-酮 以 溶剂黄146 为溶剂， 反应 0.28h， 以92%的产率得到5-hydroxy-5-(2-oxo-4-(phenylamino)-2,5-dihydrofuran-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
  参考文献：
  名称：

  A new and efficient domino strategy to indole derivatives synthesis and its C3-bisfunctionalization

  摘要：

  A series of new poly-functionalized indole derivatives were synthesized via domino reactions of alloxan monohydrate and N-aryl substituted enaminones in HOAc at room temperature. The direct C3-bisfunctionalization of indole ring was achieved in a one-pot operation. The reaction is easy to perform simply by mixing common reactants in acetic acid. The reaction proceeds at fast rates and can be finished within 24 min, which makes workup convenient to give good to excellent chemical yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.120