(6E,8S,9S,10R,11E)-9,10,13-trihydroxy-8-methoxy-12-methyltrideca-6,11-dienoic acid | 1253795-83-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (6E,8S,9S,10R,11E)-9,10,13-trihydroxy-8-methoxy-12-methyltrideca-6,11-dienoic acid
• CAS: 1253795-83-3
• 化学式: C₁₅H₂₆O₆
• 分子量: 302.368
• InChiKey: GJZBCZLJSNFEIK-XZPAOFTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以81%的产率得到(6E,8S,9S,10R,11E)-9,10,13-trihydroxy-8-methoxy-12-methyltrideca-6,11-dienoic acid
  参考文献：
  名称：

  Synthesis of congeners of migrastatin and dorrigocin A from d-xylose

  摘要：

  Migrastatin and dorrigocin A analogues have potential as anti-metastatic agents that act by targeting the actin-bundling protein, fascin. Syntheses of close structural analogues of these agents have been achieved. Wittig and Ando olefination reactions with an aldehyde obtained from D-xylose, respectively, gave two trisubstituted alkene intermediates that were then elaborated into either macrolactone or macrolactam analogues of migrastatin or to an acyclic dorrigocin A analogue. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.141

文献信息

• Synthesis of congeners of migrastatin and dorrigocin A from d-xylose
  作者：Ying Zhou、Paul V. Murphy

  DOI：10.1016/j.tetlet.2010.07.141

  日期：2010.10

  Migrastatin and dorrigocin A analogues have potential as anti-metastatic agents that act by targeting the actin-bundling protein, fascin. Syntheses of close structural analogues of these agents have been achieved. Wittig and Ando olefination reactions with an aldehyde obtained from D-xylose, respectively, gave two trisubstituted alkene intermediates that were then elaborated into either macrolactone or macrolactam analogues of migrastatin or to an acyclic dorrigocin A analogue. (C) 2010 Elsevier Ltd. All rights reserved.