Methyl 3-acetyloxy-4-chlorobutanoate | 106372-90-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 3-acetyloxy-4-chlorobutanoate
• CAS: 106372-90-1
• 化学式: C₇H₁₁ClO₄
• 分子量: 194.615
• InChiKey: FTXGAPHBGVCTHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-3-羟基丁酸甲酯 、 乙酸酐 在 4-二甲氨基吡啶 作用下， 以 乙酸乙酯 为溶剂， 以100%的产率得到Methyl 3-acetyloxy-4-chlorobutanoate
  参考文献：
  名称：

  Lentinus strigellus: a new versatile stereoselective biocatalyst for the bioreduction of prochiral ketones

  摘要：

  Growing cells of the basiodiomycete Lentinus strigellus in potato-dextrose broth have been used for the first time as a biocatalyst in the stereoselective reduction of aromatic and aliphatic ketones. Most of the aromatic ketones were converted into the corresponding optically active alcohols ill Up to > 99% enantiomeric excess under very mild reaction conditions. Among the aliphatic ketones tested, 2-octanone was enzymatically reduced by this microorganism to enantiopure (S)-2-octanol with almost complete conversion. (c) 2009 Elsevier Ltd. All Fights reserved.

  DOI：

  10.1016/j.tetasy.2009.02.008