methyl 2-(5-hydroxy-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl)propanoate | 1046120-88-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(5-hydroxy-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl)propanoate
• CAS: 1046120-88-0
• 化学式: C₁₁H₁₂N₂O₄
• 分子量: 236.227
• InChiKey: WUQXVMCIXLKXJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 2-(7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl)propanoate 在 N-氯代丁二酰亚胺 、 过氧化苯甲酰 作用下， 以 氯仿 为溶剂， 以56%的产率得到methyl 2-(5-hydroxy-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl)propanoate
  参考文献：
  名称：

  Novel Synthesis of Aza-phthalimidine Hydroxylactams

  摘要：

  A novel and convenient synthetic route for preparing aza-phthalimidine ydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process.

  DOI：

  10.1080/00397910802110180

文献信息

• Novel Synthesis of Aza-phthalimidine Hydroxylactams
  作者：Bolin Fan、Zenglu Liu、Mei Tang、Yun Xu、Xiaowei Tang、Zhenmin Mao

  DOI：10.1080/00397910802110180

  日期：2008.9.12

  A novel and convenient synthetic route for preparing aza-phthalimidine ydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process.