5H-indolo[1,2-b]thieno[2,3-d][2]benzazepine | 1067249-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 5H-indolo[1,2-b]thieno[2,3-d][2]benzazepine
• 英文别名: 3-Thia-14-azapentacyclo[12.7.0.02,6.07,12.015,20]henicosa-1(21),2(6),4,7,9,11,15,17,19-nonaene；3-thia-14-azapentacyclo[12.7.0.02,6.07,12.015,20]henicosa-1(21),2(6),4,7,9,11,15,17,19-nonaene
• CAS: 1067249-65-3
• 化学式: C₁₉H₁₃NS
• 分子量: 287.385
• InChiKey: ALSBDBMJWBGJQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(2,2-dibromovinyl)-N-[2-(3-thienyl)benzyl]aniline 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三(2-甲氧基苯基)膦 、 caesium carbonate 、 silver carbonate 作用下， 以 甲苯 为溶剂， 以54%的产率得到5H-indolo[1,2-b]thieno[2,3-d][2]benzazepine
  参考文献：
  名称：

  Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics

  摘要：

  Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.

  DOI：

  10.1021/ol801932z

文献信息

• Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics
  作者：Christopher S. Bryan、Mark Lautens

  DOI：10.1021/ol801932z

  日期：2008.10.16

  Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.