(6R)-6-allyl-3,5-cyclovitamin D₃ | 1620851-14-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (6R)-6-allyl-3,5-cyclovitamin D₃
• CAS: 1620851-14-0
• 化学式: C₃₀H₄₈O
• 分子量: 424.711
• InChiKey: BTFPAPWTCDZCON-QKCNZUCZSA-N

反应信息

• 作为产物：
  描述：

  6-oxo-3,5-cyclovitamin D₃ 、 烯丙基溴化镁 以 四氢呋喃 为溶剂， 反应 1.0h， 以33.333%的产率得到
  参考文献：
  名称：

  Synthesis of novel vitamin D3 analog with an additional ring annulated to A and seco-B rings

  摘要：

  A simple method for the synthesis of yet unknown 5E-vitamin D3 analogs with an additional six-membered ring connecting C-6 and C-19 was developed. Ring-closing metathesis (RCM) was used for efficient formation thereof from the corresponding 5E-isomers of 6-alkenyl vitamin D3 compounds which in turn were prepared from the 6-oxo-3,5-cyclovitamin D3. Reinvestigation of the Grignard reactions of this latter compound as well as the following acid-catalyzed cycloreversions showed discrepancies with the literature data describing the course of such processes.

  DOI：

  10.1016/j.steroids.2014.05.016