2,6-difluoro-1,1':4',1''-terphenyl | 1335136-53-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluoro-1,1':4',1''-terphenyl
• 英文别名: 1,3-Difluoro-2-(4-phenylphenyl)benzene；1,3-difluoro-2-(4-phenylphenyl)benzene
• CAS: 1335136-53-2
• 化学式: C₁₈H₁₂F₂
• 分子量: 266.29
• InChiKey: GQOMISAQHKDRNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二氟苯基硼酸频哪醇酯 、 4-氯联苯 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 、 caesium carbonate 、 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以91%的产率得到2,6-difluoro-1,1':4',1''-terphenyl
  参考文献：
  名称：

  Expanding the scope of the Cu assisted Suzuki–Miyaura reaction

  摘要：

  Recent advances in the development of the copper facilitated Suzuki-Miyaura reaction are described. Improvements include expansion of substrate scope to include aryl chlorides and polyhalo aryl boronates. It was found that use of S-Phos and X-Phos could accomplish the coupling of 2-pyridyl boronates to aryl chlorides and bromides in shorter reaction times and in higher yield than previously described with DPPF. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.088

文献信息

• Well‐Defined Ni(0) and Ni(II) Complexes of Bicyclic (Alkyl)(Amino)Carbene ( ^Me BICAAC): Catalytic Activity and Mechanistic Insights in Negishi Cross‐Coupling Reaction
  作者：Sandeep Kumar Thakur、Mandeep Kaur、Krishna Kumar Manar、Manu Adhikari、Angshuman Roy Choudhury、Sanjay Singh

  DOI：10.1002/chem.202202237

  日期：2022.10.21

  were coupled with phenylzinc bromides in Negishi cross-coupling reaction catalyzed by MeBICAAC-nickel complexes. The active species are deciphered by means of UV-vis, HRMS and NMR measurements and support the involvement of Ni(I)/Ni(III) species in the reaction promoted by [(MeBICAAC)2NiIICl2] pre-catalyst whereas, Ni(0)/Ni(II) cycle operates when the Ni(0) complex, [(MeBICAAC)2Ni0] was used as pre-catalyst

  在Me BICAAC-镍配合物催化的 Negishi 交叉偶联反应中，多种芳基卤化物与溴化苯基锌发生偶联。活性物质通过 UV-vis、HRMS 和 NMR 测量进行破译，并支持 Ni(I)/Ni(III) 物质参与 [( Me BICAAC) 2 Ni II Cl 2 ] 预催化剂促进的反应而当Ni(0)配合物[( Me BICAAC) 2 Ni 0 ]用作预催化剂时，Ni(0)/Ni(II)循环运行。