4-(3-(吡咯烷-1-基)丙基)苯酚 | 1009636-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(3-(吡咯烷-1-基)丙基)苯酚
• 英文名称: 4-(3-(pyrrolidin-1-yl)propyl)phenol
• 英文别名: 4-(3-Pyrrolidin-1-ylpropyl)phenol；4-(3-pyrrolidin-1-ylpropyl)phenol
• CAS: 1009636-02-5
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: JZVJLBVQVILCBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3-(吡咯烷-1-基)丙基)苯酚 、 2-溴-5,6-二甲氧基-1-茚酮 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以59%的产率得到5,6-Dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propyl)phenoxy)-indan-1-one
  参考文献：
  名称：

  2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity

  摘要：

  As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were found to inhibit AChE in the nanomolar range. The optimum inhibitor 3g exhibited 34-fold increase in AChE inhibition than donepezil and displayed neuroprotective effect against H2O2-induced cell death. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.014
• 作为产物：
  描述：

  四氢吡咯 、 4-(3-氯丙基)苯酚 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 7.0h， 生成 4-(3-(吡咯烷-1-基)丙基)苯酚
  参考文献：
  名称：

  2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity

  摘要：

  As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were found to inhibit AChE in the nanomolar range. The optimum inhibitor 3g exhibited 34-fold increase in AChE inhibition than donepezil and displayed neuroprotective effect against H2O2-induced cell death. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.014

文献信息

• Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
  申请人：GENZYME CORPORATION

  公开号：EP2266968B1

  公开（公告）日：2013-01-09
• GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE
  申请人：Genzyme Corporation

  公开号：EP2320886B1

  公开（公告）日：2017-06-28
• GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
  申请人：BioMarin Pharmaceutical Inc.

  公开号：EP3046920B1

  公开（公告）日：2021-08-04
• EP3253734B1
  申请人：——

  公开号：EP3253734B1

  公开（公告）日：2020-12-23
• 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity
  作者：Yanhong Shen、Rong Sheng、Jing Zhang、Qiaojun He、Bo Yang、Yongzhou Hu

  DOI：10.1016/j.bmc.2008.07.014

  日期：2008.8

  As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were found to inhibit AChE in the nanomolar range. The optimum inhibitor 3g exhibited 34-fold increase in AChE inhibition than donepezil and displayed neuroprotective effect against H2O2-induced cell death. (C) 2008 Elsevier Ltd. All rights reserved.