Ethyl 2-(3,4-dimethoxyphenyl)-8-methyl-4-phenylpyrimido[1,2-a]indole-10-carboxylate | 1324007-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 2-(3,4-dimethoxyphenyl)-8-methyl-4-phenylpyrimido[1,2-a]indole-10-carboxylate
• 英文别名: ethyl 2-(3,4-dimethoxyphenyl)-8-methyl-4-phenylpyrimido[1,2-a]indole-10-carboxylate
• CAS: 1324007-17-1
• 化学式: C₂₉H₂₆N₂O₄
• 分子量: 466.536
• InChiKey: DTCZLCWBGKAMMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 2-amino-5-methyl-1H-indole-3-carboxylate 、 1-(3,4-dimethoxyphenyl)-3-phenylprop-2-yn-1-one 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 生成 Ethyl 2-(3,4-dimethoxyphenyl)-8-methyl-4-phenylpyrimido[1,2-a]indole-10-carboxylate
  参考文献：
  名称：

  Three-component tandem reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates: synthesis of highly diversified pyrimido[1,2-a]indoles via sequential Sonogashira and [3+3] cyclocondensation reactions

  摘要：

  A simple, highly efficient three-component reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates, for the synthesis of highly diversified pyrimido[1,2-a]indoles has been described. The salient feature of the reaction involves sequential Sonogashira and [3+3] cyclocondensation reactions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.021

文献信息

• Three-component tandem reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates: synthesis of highly diversified pyrimido[1,2-a]indoles via sequential Sonogashira and [3+3] cyclocondensation reactions
  作者：Sahaj Gupta、Sudhir K. Sharma、Anil K. Mandadapu、Harsh M. Gauniyal、Bijoy Kundu

  DOI：10.1016/j.tetlet.2011.06.021

  日期：2011.8

  A simple, highly efficient three-component reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates, for the synthesis of highly diversified pyrimido[1,2-a]indoles has been described. The salient feature of the reaction involves sequential Sonogashira and [3+3] cyclocondensation reactions. (C) 2011 Elsevier Ltd. All rights reserved.