triptobenzene J | 191213-69-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: triptobenzene J
• 英文别名: (4bS,7S,8S,8aR)-8-(hydroxymethyl)-4b,8-dimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthrene-1,7-diol
• CAS: 191213-69-1
• 化学式: C₂₀H₃₀O₃
• 分子量: 318.456
• InChiKey: DQXZLBJNWNRITN-PIKOESSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  triptobenzene J 在 sodium hypochlorite 、 potassium dihydrogenphosphate 、 potassium nitrososulfonate 作用下， 以 甲醇 、 乙醇 、 水 、 溶剂黄146 为溶剂， 生成 雷藤二萜醌 B
  参考文献：
  名称：

  Enantiocontrolled total synthesis of the diterpenoids, triptoquinone B, C and triptocallol

  摘要：

  An efficient and enantiocontrolled synthesis of triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total synthesis of triptocallol has been achieved utilizing the same strategy. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00841-1
• 作为产物：
  描述：

  Bromomethyl-((2S,4aR)-7-isopropyl-8-methoxy-1,4a-dimethyl-2,3,4,4a,9,10-hexahydro-phenanthren-2-yloxy)-dimethyl-silane 在 三氯化铝 、 偶氮二异丁腈 、 三丁基氯化锡 、 双氧水 、 sodium cyanoborohydride 、 potassium hydrogencarbonate 、 乙硫醇 作用下， 以 四氢呋喃 、 甲醇 、 叔丁醇 为溶剂， 生成 triptobenzene J
  参考文献：
  名称：

  Enantiocontrolled total synthesis of the diterpenoids, triptoquinone B, C and triptocallol

  摘要：

  An efficient and enantiocontrolled synthesis of triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total synthesis of triptocallol has been achieved utilizing the same strategy. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00841-1

文献信息

• Enantiocontrolled total synthesis of the diterpenoids, triptoquinone B, C and triptocallol
  作者：Itsuki Yamamura、Yoko Fujiwara、Toshihiro Yamato、Osamu Irie、Kozo Shishido

  DOI：10.1016/s0040-4039(97)00841-1

  日期：1997.6

  An efficient and enantiocontrolled synthesis of triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total synthesis of triptocallol has been achieved utilizing the same strategy. (C) 1997 Elsevier Science Ltd.