cyclo[N(Me)Ala-D-N(Me)Dab-D-Leu(3R-OH)-D-aIle-N(Me)Ala-N(Me)Leu-Leu] | 1620659-33-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: cyclo[N(Me)Ala-D-N(Me)Dab-D-Leu(3R-OH)-D-aIle-N(Me)Ala-N(Me)Leu-Leu]
• 英文别名: (3S,6S,9S,12S,15R,18R,21R)-21-(2-aminoethyl)-15-[(2S)-butan-2-yl]-18-[(1R)-1-hydroxy-2-methylpropyl]-1,3,4,10,12,13-hexamethyl-6,9-bis(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptone
• CAS: 1620659-33-7
• 化学式: C₃₈H₇₀N₈O₈
• 分子量: 767.023
• InChiKey: OFLXIWRLEPGKSZ-ODTZDMBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  54
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  215
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  cyclo[D-N(Me)Abu(N3)-D-Leu(3R-OH)-D-aIle-N(Me)Ala-N(Me)Leu-Leu-N(Me)Ala] 在 水 、 三甲基膦 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以37.3%的产率得到cyclo[N(Me)Ala-D-N(Me)Dab-D-Leu(3R-OH)-D-aIle-N(Me)Ala-N(Me)Leu-Leu]
  参考文献：
  名称：

  Design, synthesis, and evaluation, derivatives of the fat-accumulation inhibitor ternatin: toward ternatin molecular probes

  摘要：

  Ternatin, a cyclic heptapeptide derived from mushroom, strongly inhibits fat accumulation in 3T3-L1 adipocytes. However, its mechanism of action remains unclear. In this Letter, we designed, synthesized, and evaluated its derivatives for use as molecular probes to isolate its target protein. Finally, we successfully established a pair of ternatin molecular probes. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.06.036

文献信息

• Design, synthesis, and evaluation, derivatives of the fat-accumulation inhibitor ternatin: toward ternatin molecular probes
  作者：Yoshinori Kawazoe、Yoko Tanaka、Sachikazu Omura、Daisuke Uemura

  DOI：10.1016/j.tetlet.2014.06.036

  日期：2014.8

  Ternatin, a cyclic heptapeptide derived from mushroom, strongly inhibits fat accumulation in 3T3-L1 adipocytes. However, its mechanism of action remains unclear. In this Letter, we designed, synthesized, and evaluated its derivatives for use as molecular probes to isolate its target protein. Finally, we successfully established a pair of ternatin molecular probes. (C) 2014 Elsevier Ltd. All rights reserved.