盐酸恩丹西酮 | 146844-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 盐酸恩丹西酮
• 中文别名: 盐酸蒽丹西酮
• 英文名称: R-Ondansentron hydrochloride
• 英文别名: (3R)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride
• CAS: 146844-89-5
• 化学式: C18H20ClN3O
• 分子量: 329.8
• InChiKey: MKBLHFILKIKSQM-BTQNPOSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.55
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
  申请人：——

  公开号：US20020107275A1

  公开（公告）日：2002-08-08

  The present invention provides novel ondansetron hydrochloride crystalline polymorphic forms and solvates. Processes for making and interconverting the polymorphic forms are also provided. Further provided are pharmaceutical compositions and therapeutic methods using the novel polymorphic forms and hydrates.

  本发明提供了新型奥昔替韦盐酸盐结晶多型形式和溶剂合物。还提供了制备和相互转化多型形式的方法。此外，还提供了使用新型多型形式和水合物的药物组合物和治疗方法。
• Method of treating cancers with SAHA and pemetrexed
  申请人：Pluda James

  公开号：US20070117815A1

  公开（公告）日：2007-05-24

  The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of an anti-cancer agent. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.

  本发明涉及一种治疗需要的受试者癌症的方法，通过向需要的受试者施用一定量的组蛋白去乙酰化酶（HDAC）抑制剂或其药用可接受的盐或水合物的第一量，以及一定量的抗癌药物。HDAC抑制剂和抗癌药物可以被施用以包含治疗有效量。在各种方面，HDAC抑制剂和抗癌药物的效果可能是相加的或协同的。
• [EN] COMBINATION IMMUNOREGULATION AND USES THEREOF<br/>[FR] IMMUNORÉGULATION COMBINÉE ET UTILISATIONS ASSOCIÉES
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2020198338A1

  公开（公告）日：2020-10-01

  The present disclosure relates to compositions and methods for regulating the immune system and for treating cancers and other immune disorders.

  本公开涉及调节免疫系统和治疗癌症及其他免疫性疾病的组合物和方法。
• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• [EN] TUCARESOL DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE TUCARESOL ET LEURS UTILISATIONS
  申请人：BEYONDSPRING PHARMACEUTICALS INC

  公开号：WO2021096811A1

  公开（公告）日：2021-05-20

  Disclosed herein are tucaresol derivative compound and composition containing the same. Also disclosed herein are methods of enhancing immune response in a subject by administering the tucaresol derivative compound or by co-administering the tucaresol derivative compound and one or more additional agents. Also disclosed herein are use of the tucaresol derivative compound and composition containing the same in the manufacture of a medicament for treating cancer or enhancing immune response in a subject.

  本文披露了一种tucaresol衍生物化合物和含有该化合物的组合物。本文还披露了通过给予tucaresol衍生物化合物或同时给予tucaresol衍生物化合物和一个或多个额外药剂来增强受试者的免疫反应的方法。本文还披露了将tucaresol衍生物化合物和含有该化合物的组合物用于制造用于治疗癌症或增强受试者免疫反应的药物的用途。