9-(3-ethoxy-2-hydroxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione | 1310490-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 9-(3-ethoxy-2-hydroxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 1310490-78-8
• 化学式: C₂₅H₃₀O₅
• 分子量: 410.51
• InChiKey: FMKVLKXRVDOHQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-乙氧基水杨醛 、 5,5-二甲基-1,3-环己二酮 在 indium(III) chloride 作用下， 反应 0.92h， 以87%的产率得到9-(3-ethoxy-2-hydroxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
  参考文献：
  名称：

  An efficient one-pot solvent-free synthesis and photophysical properties of 9-aryl/alkyl-octahydroxanthene-1,8-diones

  摘要：

  A facile and efficient protocol for the synthesis of 9-aryl/alky1-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8-octahydroxanthene-1,8-diones has been developed by one-pot reaction of dimedone with aldehydes in the presence of InCl3 or P2O5 under solvent-free conditions. The optical behaviors of the xanthenediones have been investigated by UV vis and fluorescence spectroscopy. The present approach offers the advantages of simple methodology, clean and mild reaction, high atom-economy, short reaction time, low environmental impact, wide substrate scope, high yield, and excellent purity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.078

文献信息

• An efficient one-pot solvent-free synthesis and photophysical properties of 9-aryl/alkyl-octahydroxanthene-1,8-diones
  作者：Girijesh K. Verma、Keshav Raghuvanshi、Rajiv K. Verma、Pratibha Dwivedi、M.S. Singh

  DOI：10.1016/j.tet.2011.03.078

  日期：2011.5

  A facile and efficient protocol for the synthesis of 9-aryl/alky1-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8-octahydroxanthene-1,8-diones has been developed by one-pot reaction of dimedone with aldehydes in the presence of InCl3 or P2O5 under solvent-free conditions. The optical behaviors of the xanthenediones have been investigated by UV vis and fluorescence spectroscopy. The present approach offers the advantages of simple methodology, clean and mild reaction, high atom-economy, short reaction time, low environmental impact, wide substrate scope, high yield, and excellent purity. (C) 2011 Elsevier Ltd. All rights reserved.