dimethyl 2-benzyl-2-[(E)-4-hydroxy-4-phenylbut-2-enyl]propanedioate | 1311468-13-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dimethyl 2-benzyl-2-[(E)-4-hydroxy-4-phenylbut-2-enyl]propanedioate
• CAS: 1311468-13-9
• 化学式: C₂₂H₂₄O₅
• 分子量: 368.43
• InChiKey: IHZGHPODHQIPFB-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dimethyl 2-benzyl-2-[(E)-4-hydroxy-4-phenylbut-2-enyl]propanedioate 在 silver hexafluoroantimonate 、 三苯基膦氯金 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到2,2-dimethyl 4-[(E)-2-phenylethenyl]-1,2,3,4-tetrahydronaphthalene-2,2-dicarboxylate
  参考文献：
  名称：

  Gold catalyzed carbocyclization of phenyl substituted allylic acetates to synthesize benzocycle derivatives

  摘要：

  An efficient and environmentally benign method was developed to synthesize the benzocycles from phenyl substituted allylic acetates through gold catalyzed Friedel-Crafts type carbocyclization reaction. Different substitution patterns were investigated, which gave a series of benzocyclohexane derivatives in moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.142

文献信息

• Gold catalyzed carbocyclization of phenyl substituted allylic acetates to synthesize benzocycle derivatives
  作者：Heng Liu、Ya-Hui Wang、Li-Li Zhu、Xiao-Xiao Li、Wen Zhou、Zili Chen、Wen-Xiang Hu

  DOI：10.1016/j.tetlet.2011.03.142

  日期：2011.6

  An efficient and environmentally benign method was developed to synthesize the benzocycles from phenyl substituted allylic acetates through gold catalyzed Friedel-Crafts type carbocyclization reaction. Different substitution patterns were investigated, which gave a series of benzocyclohexane derivatives in moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.