ethoxy-propiolic acid ethyl ester | 98272-60-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethoxy-propiolic acid ethyl ester
• 英文别名: Aethoxy-propiolsaeure-aethylester；3-Ethoxy-propynoic acid ethyl ester；ethyl 3-ethoxyprop-2-ynoate
• CAS: 98272-60-7
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: RHUHQEZZVJXMLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine 、 左旋环氧氯丙烷 、 对环己基苯酚 、 ethoxy-propiolic acid ethyl ester 、 乙氧基乙炔 、 氯甲酸乙酯 在 二氯甲烷 、 silica gel 、 Ammonia methanol dichloromethane 作用下， 以 乙醇 为溶剂， 反应 6.25h， 以to provide 0.544 g of the title compound as a white solid的产率得到(S)-2-(4-cyclohexyl-phenoxymethyl)-5-ethoxy-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
  参考文献：
  名称：

  SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

  摘要：

  本发明涉及一系列取代二氢和四氢噁唑嘧啶酮，具体地，涉及一系列式(I)的2-取代-2,3-二氢噁唑并[3,2-a]嘧啶-7-酮和2-取代-2,3,5,6-四氢噁唑并[3,2-a]嘧啶-7-酮：其中p，n，X，Y，R1，R2，R3，R4，R5，R6，R7和R8如所定义。本发明还涉及制备这些化合物的方法，包括新型中间体。本发明的化合物是代谢型谷氨酸受体(mGluR)的调节剂，特别是mGluR2受体。因此，本发明的化合物在制药领域中有用，特别是在治疗和/或预防各种中枢神经系统疾病(CNS)，包括但不限于急性和慢性神经退行性疾病、精神病、惊厥、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐等方面。

  公开号：

  US20100075994A1
• 作为产物：
  描述：

  乙氧基乙炔 在 乙醚 、 甲基锂 作用下， 生成 ethoxy-propiolic acid ethyl ester
  参考文献：
  名称：

  Arens et al., Recueil des Travaux Chimiques des Pays-Bas, 1956, vol. 75, p. 1459,1467

  摘要：

  DOI：

文献信息

• Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof
  申请人：Cao Bin

  公开号：US08642603B2

  公开（公告）日：2014-02-04

  The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

  本发明涉及一系列取代的二氢和四氢噁唑嘧啶酮，具体地说，涉及一系列式(I)的2-取代-2,3-二氢噁唑并[3,2-a]嘧啶-7-酮和2-取代-2,3,5,6-四氢噁唑并[3,2-a]嘧啶-7-酮，其中p，n，X，Y，R1，R2，R3，R4，R5，R6，R7和R8如本文所定义。本发明还涉及制备这些化合物的方法，包括新的中间体。本发明的化合物是代谢型谷氨酸受体（mGluR）的调节剂，特别是mGluR2受体。因此，本发明的化合物在制药领域中有用，特别是在治疗和/或预防各种中枢神经系统疾病（CNS）方面，包括但不限于急性和慢性神经退行性疾病、精神病、惊厥、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐。
• RESIN COMPOSITION FOR PROTECTIVE FILM
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP1672026A1

  公开（公告）日：2006-06-21

  The present invention relates to a resin composition for protective films which comprises an epoxy resin having two or more epoxy groups, a curing agent, a curing accelerator, a solvent, and a colloidal slurry of fine silica particles having an average particle diameter, as determined by conversion from the specific surface area, of 50 nm or smaller, a pH of 6 to 8, and an alkali metal content of 5 ppm or lower. The resin composition gives a protective film which satisfies adhesiveness and visible-light transmission, which are performances conventionally required. The protective film further has high surface smoothness even when the substrate surface is not smoothed. The resin composition has satisfactory storage stability and does not stain liquid crystal. Furthermore, a cured film obtained from the resin composition has excellent high-temperature resistance, especially ITO resistance. The resin composition is hence suitable for use in forming a protective film for the colored resin films of color filters for liquid-crystal display.

  本发明涉及一种用于保护膜的树脂组合物，该组合物由具有两个或两个以上环氧基团的环氧树脂、固化剂、固化促进剂、溶剂和细二氧化硅颗粒胶体浆液组成，细二氧化硅颗粒的平均颗粒直径（根据比表面积换算确定）为 50 nm 或更小、pH 值为 6 至 8、碱金属含量为 5 ppm 或更低。这种树脂组合物可提供一种保护膜，满足粘附性和可见光透射率等常规性能要求。即使基材表面未被磨平，保护膜的表面平滑度也很高。该树脂组合物具有令人满意的储存稳定性，并且不会弄脏液晶。此外，由该树脂组合物制成的固化膜具有出色的耐高温性，尤其是耐 ITO 性。因此，该树脂组合物适用于为液晶显示器彩色滤光片的彩色树脂薄膜形成保护膜。
• Composition for protective film, method of using the same, and use thereof
  申请人：——

  公开号：US20040077800A1

  公开（公告）日：2004-04-22

  The object of the present invention is to provide a composition for protective films excellent in adhesion and visible light transmittance that can form a protective film having high surface smoothness even on a substrate whose surface has not been smoothed and has extremely high resistance to thermal yellowing without staining liquid crystals. Especially, when used for protective films of color filters for liquid-crystal displays, the protective films have the excellent high-temperature resistance under ITO (yellowing resistance) vapor deposition. The composition for protective films is characterized by comprising (1) an epoxy resin having at least two epoxy groups in one molecule, (2) apolyphenol compound having a cyclic terpene skeleton, and (3) an imidazole-type curing promoter.
• Resin composition for protective film
  申请人：Umeyama Chie

  公开号：US20070134498A1

  公开（公告）日：2007-06-14

  The present invention relates to a resin composition for protective films which comprises an epoxy resin having two or more epoxy groups, a curing agent, a curing accelerator, a solvent, and a colloidal slurry of fine silica particles having an average particle diameter, as determined by conversion from the specific surface area, of 50 nm or smaller, a pH of 6 to 8, and an alkali metal content of 5 ppm or lower. The resin composition gives a protective film which satisfies adhesiveness and visible-light transmission, which are performances conventionally required. The protective film further has high surface smoothness even when the substrate surface is not smoothed. The resin composition has satisfactory storage stability and does not stain liquid crystal. Furthermore, a cured film obtained from the resin composition has excellent high-temperature resistance, especially ITO resistance. The resin composition is hence suitable for use in forming a protective film for the colored resin films of color filters for liquid-crystal display.
• US8642603B2
  申请人：——

  公开号：US8642603B2

  公开（公告）日：2014-02-04