1-methyl-4-(m-anisyl)pyrazolo<3,4-d>pyrimidine | 87412-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-methyl-4-(m-anisyl)pyrazolo<3,4-d>pyrimidine
• 英文别名: 4-(3-Methoxyphenyl)-1-methylpyrazolo[3,4-d]pyrimidine
• CAS: 87412-68-8
• 化学式: C₁₃H₁₂N₄O
• 分子量: 240.264
• InChiKey: SVLDWKAEQLBUHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  52.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲基-4-氨基-1H-吡唑并[3,4-D]嘧啶 、 苯甲醚 、 亚硝酸正戊酯 、 对甲苯磺酸 生成 1-methyl-4-(m-anisyl)pyrazolo<3,4-d>pyrimidine
  参考文献：
  名称：

  PRESS, J. B.;EUDY, N. H.;MORTON, G. O., J. ORG. CHEM., 1983, 48, N 24, 4605-4611

  摘要：

  DOI：

文献信息

• Aryl coupling reactions of pyrazolo[3,4-d]pyrimidin-4-yl radicals
  作者：Jeffery B. Press、Nancy H. Eudy、George O. Morton

  DOI：10.1021/jo00172a033

  日期：1983.12
• USE OF DIANHYDROGALACTITOL AND ANALOGS OR DERIVATIVES THEREOF TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND OVARIAN CANCER
  申请人：Del Mar Pharmaceuticals

  公开号：EP3125920A2

  公开（公告）日：2017-02-08
• [EN] USE OF DIANHYDROGALACTITOL AND ANALOGS OR DERIVATIVES THEREOF TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND OVARIAN CANCER<br/>[FR] UTILISATION DE DIANHYDROGALACTITOL ET DE LEURS ANALOGUES OU DÉRIVÉS DANS LE TRAITEMENT DU CARCINOME NON À PETITES CELLULES DES POUMONS ET DU CANCER DES OVAIRES
  申请人：DEL MAR PHARMACEUTICALS

  公开号：WO2015154064A2

  公开（公告）日：2015-10-08

  The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and thymidine kinase inhibitors; the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.