N-hydroxy-9H-pyrido[3,4-b]indole-3-carboxamide | 78538-94-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-hydroxy-9H-pyrido[3,4-b]indole-3-carboxamide
• CAS: 78538-94-0
• 化学式: C₁₂H₉N₃O₂
• 分子量: 227.222
• InChiKey: NVUAEVAHFQKKLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase
  申请人：Forum Pharmaceuticals, Inc.

  公开号：US20170000749A1

  公开（公告）日：2017-01-05

  This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

  这份披露涉及用于抑制组蛋白去乙酰化酶和治疗认知障碍或缺陷的化合物。更具体地，该披露提供了公式（I）的化合物 其中 Q、J、L和Z如规范中所定义。
• [EN] HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE<br/>[FR] INHIBITEURS DE VIH-INTEGRASE, COMPOSITIONS PHARMACEUTIQUES ET METHODES D'UTILISATION DESDITS INHIBITEURS
  申请人：PFIZER

  公开号：WO2004067531A1

  公开（公告）日：2004-08-12

  Beta-carboline hydroxamic acid compounds represented by formula (I) and formula (lb) are described, wherein: R1, R2, R3, R4, R5, and R6 are independently selected from hydrogen, halogen, C1_C6 alkyl, aikoxy C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -ORc, -NO2, and -N(Rc)2, each Rc is Independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-Ca alkynyl; R7 Is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, all of which are optionally substituted by one or more substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl; C2-C6 alkynyl, aryl, cycloalkyl, heterocycioalkyl, and heteroaryl, wherein said aryl, cydoalkyi, and heterocycloalkyl are optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl; R8 and R9 are independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 aikynyl, wherein said alkyl, alkenyl, and alkynyl are optionally substituted with one or more substituents independently selected from halogen, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group, wherein said aryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.

  描述了由式（I）和式（lb）表示的β-咔啉羟肟酸化合物，其中：R1、R2、R3、R4、R5和R6分别独立地选自氢、卤素、C1-C6烷基、氧基C1-C6烷基、C2-C6烯基、C2-C6炔基、-ORc、-NO2和-N(Rc)2，每个Rc独立地选自氢、C1-C6烷基、C2-C6烯基和C2-Ca炔基；R7为C1-C6烷基、C2-C6烯基或C2-C6炔基，这些基都可以选择性地被一个或多个取代基取代，这些取代基独立地选自卤素、C1-C6烷基、C2-C6烯基、C2-C6炔基、芳基、环烷基、杂环烷基和杂芳基，其中所述芳基、环烷基和杂环烷基可以选择性地被一个或多个取代基取代，这些取代基独立地选自卤素、C1-C6烷基、C2-C6烯基和C2-C6炔基；R8和R9独立地选自氢、C1-C6烷基、C2-C6烯基和C2-C6炔基，其中所述烷基、烯基和炔基可以选择性地被一个或多个取代基取代，这些取代基独立地选自卤素、芳基、环烷基、杂环烷基和杂芳基，其中所述芳基、环烷基和杂环烷基可以选择性地被一个或多个取代基取代，这些取代基独立地选自卤素、C1-C6烷基、C2-C6烯基和C2-C6炔基。这些β-咔啉羟肟酸化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的活性，并用于治疗HIV整合酶介导的疾病和症状。
• Inhibitors of Histone Deacetylase
  申请人：Deziel Robert

  公开号：US20080207590A1

  公开（公告）日：2008-08-28

  This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

  该发明涉及用于抑制组蛋白去乙酰化酶的化合物。更具体地，该发明提供了式（I）中Q、J、L和Z所定义的化合物。
• METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE
  申请人：Rogers Kathryn

  公开号：US20110288070A1

  公开（公告）日：2011-11-24

  This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein (I), Q, J, L and Z are as defined in the specification.

  本公开涉及化合物用于抑制组蛋白去乙酰化酶并治疗认知障碍或缺陷。更具体地，本公开提供了式（I）的化合物，其中（I），Q，J，L和Z如规范中所定义。
• INHIBITORS OF HISTONE DEACETYLASE
  申请人：Déziel Robert

  公开号：US20110196147A1

  公开（公告）日：2011-08-11

  This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

  本发明涉及用于抑制组蛋白去乙酰化酶的化合物。更具体地，本发明提供了公式（I）中Q、J、L和Z所定义的化合物。