| 1427730-08-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1427730-08-2
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: YXYNENNSPUMBRT-VURMDHGXSA-N

反应信息

• 作为反应物：
  描述：

  在 葡萄糖 、 GDH 、 nicotinamide adenine dinucleotide phosphate 作用下， 以 二甲基亚砜 为溶剂， 反应 72.0h， 以91%的产率得到
  参考文献：
  名称：

  旧的黄色酶介导的还原β-氰基-α，β-不饱和酯的合成，用于手性结构单元的合成：反应的立体化学分析†

  摘要：

  为了扩大这种反应在制备有机化学领域中的适用性，研究了贝克酵母和老黄酶介导的β-氰基-α，β-不饱和酯的碳-碳双键还原。对映选择性还原这些双官能化基板的合成显着性示出通过考虑饱和手性氰基酯转化为γ 2-用于折叠剂化学应用的氨基酸衍生物。通过氘标记实验仔细分析了生物转化的立体化学结果。该分析的结果被用来合理化底物控制对某类烯-还原酶介导的还原反应的立体选择性的影响。开发了一个简单的模型来描述OYE1-3酶结合位点内底物最佳排列的结构前提。

  DOI：

  10.1039/c3cy20804d

文献信息

• Rationalisation of the stereochemical outcome of ene-reductase-mediated bioreduction of α,β-difunctionalised alkenes
  作者：Elisabetta Brenna、Michele Crotti、Francesco G. Gatti、Alessia Manfredi、Daniela Monti、Fabio Parmeggiani、Andrea Pugliese、Davila Zampieri

  DOI：10.1016/j.molcatb.2013.12.020

  日期：2014.3

  The OYE1-3-mediated reductions of some alpha,beta-difunctionalised alkenes, showing on the double bond a nitrile and ester group, are submitted to a careful stereochemical analysis, in order to identify which of the two electron-withdrawing groups (EWGs) is responsible for the activation of the C=C double bond towards reduction and for establishing hydrogen bond interactions within the binding pocket of the enzymes. The results show that for most of these substrates the activating EWG is the CN moiety linked to the prostereogenic olefinic carbon atom. The final stereochemical outcome can be explained through the empirical model which has been recently developed for difunctionalised alkenes activated by carbonyl/carboxyl containing EWGs.In a single case the activation is due to the COOR group linked to the less substituted olefinic carbon atom: an alternative empirical model is established for this kind of substrates, taking into consideration the OYE-catalysed reductions of beta,beta'-disubstituted-a-monofunctionalised alkenes. (C) 2014 Elsevier B.V. All rights reserved.
• ADHESIVES, SEALANTS AND COATINGS CONTAINING GLASS PARTICLES AS A FILLER
  申请人：Loth Helmut

  公开号：US20080287574A1

  公开（公告）日：2008-11-20

  The invention relates to chemically or physically curable compositions suitable as adhesives or sealants or coating materials, which compositions contain at least one binding agent selected from the group comprising crosslinkable or polymerizable monomers, prepolymers, or polymers, as well as at least one filler. The filler proportion is 0.2 to 70 wt % based on the total weight of the compositions, and at least a portion of the filler is made up of glass particles having a particle size from 100 nm to 20 μm, which have been obtained by comminuting foamed neutral or acid glass.