3-ethoxy-2-phenylindole | 50615-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-ethoxy-2-phenylindole
• 英文别名: 3-ethoxy-2-phenyl-1H-indole
• CAS: 50615-04-8
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: GDHOXPLQJBMWLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-ethoxy-2-phenylindole 以 甲醇 为溶剂， 以3%的产率得到6-ethoxy-2-phenylindole
  参考文献：
  名称：

  Photo-induced Rearrangement of 1-Ethoxy-2-phenylindole

  摘要：

  DOI：

  10.3987/com-98-8345

文献信息

• BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT
  申请人：Duquesne University of The Holy Spirit

  公开号：EP2670244A2

  公开（公告）日：2013-12-11
• [EN] BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT<br/>[FR] INHIBITEURS PYRIMIDINES BICYCLIQUES ET TRICYCLIQUES DE TYROSINE KINASE AYANT UNE ACTIVITÉ ANTITUBULINE, ET MÉTHODES DE TRAITEMENT D'UN PATIENT
  申请人：UNIV HOLY GHOST DUQUESNE

  公开号：WO2012106522A2

  公开（公告）日：2012-08-09

  Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.