(R)-1-[1-(2-bromoethoxymethyl)-2-(tetradecyloxy)]tetradecane | 869802-93-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (R)-1-[1-(2-bromoethoxymethyl)-2-(tetradecyloxy)]tetradecane
• CAS: 869802-93-7
• 化学式: C₃₃H₆₇BrO₃
• 分子量: 591.797
• InChiKey: HNJIYDKAWHFWOA-MGBGTMOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  37.0
• 可旋转键数：
  33.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (R)-1-[1-(2-bromoethoxymethyl)-2-(tetradecyloxy)]tetradecane 以 甲醇 、 乙醇 为溶剂， 反应 228.0h， 生成
  参考文献：
  名称：

  Synthesis of cationic cardiolipin analogues

  摘要：

  An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2005.06.001
• 作为产物：
  描述：

  (R)-2-[2,3-bis-(tetradecyloxy)propoxy]ethanol 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到(R)-1-[1-(2-bromoethoxymethyl)-2-(tetradecyloxy)]tetradecane
  参考文献：
  名称：

  Synthesis of cationic cardiolipin analogues

  摘要：

  An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2005.06.001