2-(2-methyl-5-nitrophenyl)-1H-pyrrole | 1351556-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(2-methyl-5-nitrophenyl)-1H-pyrrole
• CAS: 1351556-98-3
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: GMLYXLKMTKYVSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吡咯 、 (2-Me-5-O2NC6H3)2I+Br- 在 sodium hydroxide 作用下， 反应 10.0h， 以83%的产率得到2-(2-methyl-5-nitrophenyl)-1H-pyrrole
  参考文献：
  名称：

  Direct Arylation of Arene and N-Heteroarenes with Diaryliodonium Salts without the Use of Transition Metal Catalyst

  摘要：

  A novel and simple transition metal-free direct arylation of arene and N-heteroarenes with diaryliodonium salts has been developed. This cross-coupling reaction is promoted only by base and gives the desired products in moderate to good yields.

  DOI：

  10.1021/jo202150t

文献信息

• Direct Arylation of Arene and <i>N</i>-Heteroarenes with Diaryliodonium Salts without the Use of Transition Metal Catalyst
  作者：Jun Wen、Ruo-Yi Zhang、Shan-Yong Chen、Ji Zhang、Xiao-Qi Yu

  DOI：10.1021/jo202150t

  日期：2012.1.6

  A novel and simple transition metal-free direct arylation of arene and N-heteroarenes with diaryliodonium salts has been developed. This cross-coupling reaction is promoted only by base and gives the desired products in moderate to good yields.