(2S)-4-[[(2R)-2,4-dihydroxybutanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid | 1350543-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (2S)-4-[[(2R)-2,4-dihydroxybutanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
• CAS: 1350543-77-9
• 化学式: C₂₃H₂₆N₂O₇
• 分子量: 442.469
• InChiKey: WPTTWLHNELUFKB-VQTJNVASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 palladium 10% on activated carbon 、 氢气 、 溶剂黄146 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以68%的产率得到(2S)-4-[[(2R)-2,4-dihydroxybutanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
  参考文献：
  名称：

  Preparation of pseudo glycoamino acid and its application to glycopeptide synthesis

  摘要：

  A pseudo glycoamino acid composed of a 1,3-diol structure and an amino acid was synthesized. This amino acid analog can act as an alternative acceptor to an amino acid containing GlcNAc for transglycosylation by Endo-M. A pseudo glycopeptide was synthesized using the pseudo glycoamino acid by a solid phase procedure. We attempted transglycosylation of N-glycan to the peptide using Endo-M. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.121

文献信息

• Preparation of pseudo glycoamino acid and its application to glycopeptide synthesis
  作者：Yusuke Tomabechi、Toshiyuki Inazu

  DOI：10.1016/j.tetlet.2011.09.121

  日期：2011.11

  A pseudo glycoamino acid composed of a 1,3-diol structure and an amino acid was synthesized. This amino acid analog can act as an alternative acceptor to an amino acid containing GlcNAc for transglycosylation by Endo-M. A pseudo glycopeptide was synthesized using the pseudo glycoamino acid by a solid phase procedure. We attempted transglycosylation of N-glycan to the peptide using Endo-M. (C) 2011 Elsevier Ltd. All rights reserved.