2,5-dioxopyrrolidin-1-yl 6-(3-(3-methyl-3H-diazirin-3-yl)propanamido)hexanoate | 1435895-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,5-dioxopyrrolidin-1-yl 6-(3-(3-methyl-3H-diazirin-3-yl)propanamido)hexanoate
• 英文别名: LC-SDA(NHS-LC-Diazirine) (succinimidyl 6-(4,4'-azipentanamido)hexanoate)；(2,5-dioxopyrrolidin-1-yl) 6-[3-(3-methyldiazirin-3-yl)propanoylamino]hexanoate
• CAS: 1435895-19-4
• 化学式: C₁₅H₂₂N₄O₅
• 分子量: 338.363
• InChiKey: DYNYVLFTFJHMCW-UHFFFAOYSA-N

物化性质

• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,5-dioxopyrrolidin-1-yl 6-(3-(3-methyl-3H-diazirin-3-yl)propanamido)hexanoate 在 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.5h， 生成
  参考文献：
  名称：

  BIFUNCTIONAL PHOTOCROSSLINKING PROBES FOR COVALENT CAPTURE OF PROTEIN-NUCLEIC ACID COMPLEXES IN CELLS

  摘要：

  A new class of molecular probes is provided for real, efficient, stable, and selective capture of protein-nucleic acid complexes inside cells. The molecular probes have a nucleic acid-binding functional group and a photo-reactive diazirine based functional group, separated by a linker of a selected length or with a multi-arm core, thereby generating a photocrosslink between nucleic acids and proteins in close proximity. This is useful in various chromatin research, including the study of interactions between transcription factors and DNA.

  公开号：

  WO2024015963A2

文献信息

• Photoactive grafted polysaccharide and use thereof in cosmetics
  申请人：L'OREAL

  公开号：US10456607B2

  公开（公告）日：2019-10-29

  The invention relates to a polysaccharide polymer of formula (I): PS—(O—CO-L-X)a(OH)b  (I) in which PS denotes the basic backbone of the polysaccharide bearing the hydroxyl groups; L is a divalent hydrocarbon-based group comprising from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of OH groups substituted with the photoactive group; b denotes the content of unsubstituted free OH groups; a being between 0.02 and 0.5; b being between 0.5 and 0.98; and a+b=1. The invention also relates to a composition comprising the polymer (I) in a physiologically acceptable medium, and also to a cosmetic process for caring for the skin, comprising the topical application to the skin of said composition and exposure of the treated skin to light radiation.

  本发明涉及一种式 (I) 的多糖聚合物： PS-(O-CO-L-X)a(OH)b (I) 其中 PS 表示带有羟基的多糖基本骨架； L 是由 1 至 20 个碳原子组成的二价烃基； X 表示叠氮或重氮基类型的光活性基团； a 表示被光活性基团取代的 OH 基团的含量； b 表示未取代的游离 OH 基团的含量； a 介于 0.02 和 0.5 之间；b 介于 0.5 和 0.98 之间； a+b=1。 本发明还涉及一种包含在生理上可接受的介质中的聚合物(I)的组合物，还涉及一种用于护理皮肤的美容工艺，包括将所述组合物局部施用到皮肤上，并将处理过的皮肤暴露在光辐射下。
• Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel
  作者：Lalit Kumar Sharma、Pauline M. Cupit、Tino Goronga、Thomas R. Webb、Charles Cunningham

  DOI：10.1016/j.bmcl.2014.04.014

  日期：2014.6

  Schistosomiasis is a highly prevalent neglected tropical disease caused by blood-dwelling helminths of the genus Schistosoma. Praziquantel (PZQ) is the only drug available widely for the treatment of this disease and is administered in racemic form, even though only the (R)-isomer has significant anthelmintic activity. Progress towards the development of a second generation of anthelmintics is hampered by a lack of understanding of the mechanism of action of PZQ. In this Letter, we report an efficient protocol for the small-scale separation of enantiomers of 2 (hydrolyzed PZQ) using supercritical fluid chromatography (SFC). The enantiopure 2 was then used to develop several molecular probes, which can potentially be used to help identify the protein target of PZQ and study its mode of action. (C) 2014 Elsevier Ltd. All rights reserved.
• COSMETIC METHOD FOR CONTROLLING ODORS
  申请人：L'OREAL

  公开号：US20170360678A1

  公开（公告）日：2017-12-21

  The invention relates to a cosmetic method for treating human body odors. Said method includes: (i) applying, to the skin, a composition containing a polymer (I): wherein R′ is, separately, H or an acetyl grouping or a —CO-L-X grouping, the polymer containing at least one R′═—CO-L-X grouping, L being a divalent hydrocarbon group containing 1 to 20 carbon atoms, X denoting a photoactive azide or diazirine group, and n ranging from 5 to 2000; then (ii) exposing the skin to visible light. The method used on the skin can also be used on materials for deodorizing malodorous environments such as shoe soles or clothing.
• PHOTOACTIVE GRAFTED POLYSACCHARIDE AND USE THEREOF IN COSMETICS
  申请人：L'OREAL

  公开号：US20170361131A1

  公开（公告）日：2017-12-21

  The invention relates to a polysaccharide polymer of formula (I): PS—(O—CO-L-X) a (OH) b (I) in which PS denotes the basic backbone of the polysaccharide bearing the hydroxyl groups; L is a divalent hydrocarbon-based group comprising from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of OH groups substituted with the photoactive group; b denotes the content of unsubstituted free OH groups; a being between 0.02 and 0.5; b being between 0.5 and 0.98; and a+b=1. The invention also relates to a composition comprising the polymer (I) in a physiologically acceptable medium, and also to a cosmetic process for caring for the skin, comprising the topical application to the skin of said composition and exposure of the treated skin to light radiation.