(5S,7S)-5-allyl-7-(benzyloxy)-2,2,3,3,11,11,12,12-octamethyl-4,10-dioxa-3,11-disilatridecane | 1337552-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5S,7S)-5-allyl-7-(benzyloxy)-2,2,3,3,11,11,12,12-octamethyl-4,10-dioxa-3,11-disilatridecane
• 英文别名: tert-butyl-[(3S,5S)-5-[tert-butyl(dimethyl)silyl]oxy-3-phenylmethoxyoct-7-enoxy]-dimethylsilane
• CAS: 1337552-56-3
• 化学式: C₂₇H₅₀O₃Si₂
• 分子量: 478.863
• InChiKey: RCGMESYCTGBSDG-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.34
• 重原子数：
  32
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5S,7S)-5-allyl-7-(benzyloxy)-2,2,3,3,11,11,12,12-octamethyl-4,10-dioxa-3,11-disilatridecane 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 甲醇 、 Stryker's reagent 、 苯硅烷 、 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 48.5h， 生成 (5S, 6S, 12S, 14S)-14-(benzyloxy)-12,16-bis((tert-dimethylsilyl)oxy)-6-hydroxy-5-methylhexadecan-8-one
  参考文献：
  名称：

  Convergent enantioselective syntheses of two potential C25-C40 subunits of (-)-caylobolide A

  摘要：

  The convergent syntheses of two possible diastereomers of the C25-C40 subunit resident in (-)-caylobolide A have been accomplished. The key reaction featured a chemoselective Ru-catalyzed cross-metathesis between a fully elaborated type I and two functionalized type II alpha,beta-unsaturated ketones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.105
• 作为产物：
  描述：

  (R)-1-((tert-butyldimethylsilyl)oxy)hex-5-en-3-ol 在 咪唑 、 4-二甲氨基吡啶 、 四氯化钛 、 四丁基碘化铵 、 sodium hydride 、 臭氧 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 62.0h， 生成 (5S,7S)-5-allyl-7-(benzyloxy)-2,2,3,3,11,11,12,12-octamethyl-4,10-dioxa-3,11-disilatridecane
  参考文献：
  名称：

  Convergent enantioselective syntheses of two potential C25-C40 subunits of (-)-caylobolide A

  摘要：

  The convergent syntheses of two possible diastereomers of the C25-C40 subunit resident in (-)-caylobolide A have been accomplished. The key reaction featured a chemoselective Ru-catalyzed cross-metathesis between a fully elaborated type I and two functionalized type II alpha,beta-unsaturated ketones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.105

文献信息

• Convergent enantioselective syntheses of two potential C25-C40 subunits of (-)-caylobolide A
  作者：Dripta DeJoarder、Michael P. Jennings

  DOI：10.1016/j.tetlet.2011.07.105

  日期：2011.7

  The convergent syntheses of two possible diastereomers of the C25-C40 subunit resident in (-)-caylobolide A have been accomplished. The key reaction featured a chemoselective Ru-catalyzed cross-metathesis between a fully elaborated type I and two functionalized type II alpha,beta-unsaturated ketones. (C) 2011 Elsevier Ltd. All rights reserved.