4-(4,5-二氢-1H-咪唑-2-基氨基)丁酸 | 24341-66-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-(4,5-二氢-1H-咪唑-2-基氨基)丁酸
• 英文名称: 4-(2-imidazolin-2-ylamino)butyric acid
• 英文别名: 2-(3-Carboxypropylamino)-2-imidazolin；4-(4,5-dihydro-1H-imidazol-2-ylamino)-butyric acid；4-(4,5-Dihydro-1H-imidazol-2-ylamino)-buttersaeure；4-(4,5-dihydro-1H-imidazol-3-ium-2-ylamino)butanoate
• CAS: 24341-66-0
• 化学式: C₇H₁₃N₃O₂
• mdl: MFCD03724084
• 分子量: 171.199
• InChiKey: YMSWNNBAZYUSOC-UHFFFAOYSA-N

物化性质

• 熔点：
  224-225 °C(Solv: methanol (67-56-1))
• 沸点：
  354.9±44.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  73.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  4-(4,5-二氢-1H-咪唑-2-基氨基)丁酸 以88%的产率得到
  参考文献：
  名称：

  GREENHILL, J. V.;ISMAIL, M. J.;EDWARDS, PH. N.;TAYLOR, P. J., J. CHEM. SOC. PERKIN TRANS., 1985, N 8, 1255-1264

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲硫基-2-咪唑啉 、 4-氨基丁酸 以91%的产率得到
  参考文献：
  名称：

  GREENHILL, J. V.;ISMAIL, M. J.;EDWARDS, PH. N.;TAYLOR, P. J., J. CHEM. SOC. PERKIN TRANS., 1985, N 8, 1255-1264

  摘要：

  DOI：

文献信息

• Biphenyl derivatives and the use thereof as integrin inhibitors
  申请人：——

  公开号：US20040010023A1

  公开（公告）日：2004-01-15

  The invention relates to novel biphenyl derivatives of the general formula (I), wherein R 4 represents an aromatic heterocycle, and to the physiologically acceptable salts or solvates thereof. The inventive compounds are integrin inhibitors and are used for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections and restenosis following angioplasty or for pathological processes that are maintained or propagated by angiogenesis. 1

  该发明涉及一种通式（I）的新型联苯衍生物，其中R4代表芳香杂环，并且其生理上可接受的盐或溶剂化合物。这些创新化合物是整合素抑制剂，用于对抗血栓形成、心肌梗死、冠心病、动脉粥样硬化、炎症、肿瘤、骨质疏松症、感染以及在血管成形术后再狭窄或由血管生成维持或传播的病理过程。
• DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION
  申请人：Dietz Ulrich

  公开号：US20130090488A1

  公开（公告）日：2013-04-11

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及溶解化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸特别是脂肪酸和含有至少一种氨基甲酰基和/或肼基团的溶解化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。溶解化合物的溶解效果与本发明所述的羧酸分离方法相结合，可用于治疗需要去除脂肪酸或从血液中分析羧酸或处理食品、药品、化学、生物燃料工业或其他工业加工过程中的其他溶液的人员。
• AMINO ACIDS: III. CYCLIC GUANIDINO ACIDS AND THEIR DERIVATIVES
  作者：D. L. Garmaise、S. O. Winthrop、Gordon A. Grant、A. F. McKay

  DOI：10.1139/v56-097

  日期：1956.6.1

  Several new cyclic guanidino acids have been prepared by the reaction of cyclic isothioureas with amino acids. The ethyl esters of some of these acids have been converted into dialkylaminoalkylamides by refluxing with dialkylaminoalkylamines in the presence of an inert solvent. A series of dialkylaminoethyl esters of the 2-(carboxyalkylamino)-2-imidazolines also have been prepared.

  已经通过环状异硫脲与氨基酸的反应制备了几种新的环状胍酸。在惰性溶剂存在下，通过与二烷基氨基烷基胺回流，已将这些酸中的一些的乙酯转化为二烷基氨基烷基酰胺。还制备了一系列2-(羧基烷基氨基)-2-咪唑啉的二烷基氨基乙酯。
• DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION
  申请人：Dietz, Ulrich

  公开号：EP3042718A1

  公开（公告）日：2016-07-13

  The present invention is directed to a device for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the herein disclosed method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the use of the separation methods for carboxylic acids as discloses herein can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及一种从油、脂肪、水乳液、水介质和有机溶液中增溶和去除羧酸，特别是脂肪酸的装置。通过制备羧酸（尤其是脂肪酸）和至少含有一个脒基和/或胍基的增溶化合物的水性微乳液或纳米乳液，利用本文公开的方法制备的设备可分别用于从油、脂肪、水性乳液、亲油介质或有机溶液中分离羧酸。增溶化合物的增溶作用与本文公开的羧酸分离方法相结合，可用于治疗需要从血液中去除脂肪酸或分析羧酸的人，或处理食品、制药、化学、生物燃料工业或其他工业加工中的其他溶液。
• Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins
  作者：Bart L. De Corte、William A. Kinney、Li Liu、Shyamali Ghosh、Livia Brunner、William J. Hoekstra、Rosemary J. Santulli、Robert W. Tuman、Judith Baker、Candace Burns、Jef C. Proost、Brett A. Tounge、Bruce P. Damiano、Bruce E. Maryanoff、Dana L. Johnson、Robert A. Galemmo

  DOI：10.1016/j.bmcl.2004.06.061

  日期：2004.10

  The synthesis and SAR of a new class of Piperidine-based alpha(v)beta(3)/alpha(v)beta(5) integrin antagonists is described. Replacement of an amide bond in a prototype isonipecotamide by a C-C isostere, and adjustment of the spacer length between the carboxylic acid and basic moieties, led to low nanomolar antagonists of alpha(v)beta(3) and alpha(v)beta(5) integrins with excellent selectivity versus alpha(IIb)beta(3). (C) 2004 Elsevier Ltd. All rights reserved.