2,6-dichloro-N-[(3,4-dimethoxyphenyl)methyl]benzamide | 895680-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichloro-N-[(3,4-dimethoxyphenyl)methyl]benzamide
• CAS: 895680-64-5
• 化学式: C₁₆H₁₅Cl₂NO₃
• 分子量: 340.206
• InChiKey: NDKRGLXBPXVLCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dichloro-N-[(3,4-dimethoxyphenyl)methyl]benzamide 在 劳森试剂 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以47.8 %的产率得到2,6-dichloro-N-(3,4-dimethoxybenzyl)benzothioamide
  参考文献：
  名称：

  硫代酰胺类ALDH₂激动剂、制备方法及应用

  摘要：

  本发明提供了硫代酰胺类ALDH2激动剂或其药学上可接受的盐或晶型或溶剂化物，结构为式I： ；其中：n为1、2、3或4，m为1、2、3或4；本发明的硫代酰胺类ALDH2激动剂具有良好的激动活性；用本发明的制备方法得到硫代酰胺类ALDH2激动剂及其组合物在用于预防、治疗和/或改善多种与ALDH2相关的疾病如醉酒、原发性高血压、2型糖尿病以及多种肿瘤类疾病的药物方面有良好应用。

  公开号：

  CN115160285B
• 作为产物：
  描述：

  3,4-二甲氧基苄胺 、 2,6-二氯苯甲酸 在 N-羟基-7-氮杂苯并三氮唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以73.5 %的产率得到2,6-dichloro-N-[(3,4-dimethoxyphenyl)methyl]benzamide
  参考文献：
  名称：

  硫代酰胺类ALDH₂激动剂、制备方法及应用

  摘要：

  本发明提供了硫代酰胺类ALDH2激动剂或其药学上可接受的盐或晶型或溶剂化物，结构为式I： ；其中：n为1、2、3或4，m为1、2、3或4；本发明的硫代酰胺类ALDH2激动剂具有良好的激动活性；用本发明的制备方法得到硫代酰胺类ALDH2激动剂及其组合物在用于预防、治疗和/或改善多种与ALDH2相关的疾病如醉酒、原发性高血压、2型糖尿病以及多种肿瘤类疾病的药物方面有良好应用。

  公开号：

  CN115160285B

文献信息

• Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10227304B2

  公开（公告）日：2019-03-12

  The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.

  本公开提供了作为线粒体醛脱氢酶-2（ALDH2）活性调节剂的式(I)化合物，以及制备这些化合物的方法。
• MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP2126574B1

  公开（公告）日：2015-12-23
• Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
  申请人：MOCHLY-ROSEN DARIA

  公开号：US20110105602A2

  公开（公告）日：2011-05-05

  The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
• Mitochondrial Aldehyde Dehyrogenase-2 Modulators and Methods of Use Thereof
  申请人：THE BOARD OF TRUSTEES OF THE LE-LAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160107996A1

  公开（公告）日：2016-04-21

  The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.
• MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS FOR PROTECTING, EXPANDING AND INCREASING THE POTENCY OF HEMATOPOIETIC STEM CELLS
  申请人：The Borad of Trustees of the Leland Stanford Junior University

  公开号：US20190083457A1

  公开（公告）日：2019-03-21

  The present disclosure provides methods of protecting and expanding hematopoietic cells. The present disclosure also provides methods of increasing the potency of hematopoietic cells. Aspects of the methods include contacting a starting population of hematopoietic cells with a therapeutically effective amount of at least one ALDH2 agonist. Aspects include in vivo, in vitro and ex vivo methods of protecting, expanding and increasing the potency of hematopoietic cells. Aspects of the methods include treating an individual who is undergoing chemotherapy or radiation treatment for cancer, has been exposed to damaging toxins, has a genetic disease that leads to HSC damage, bone marrow failure, an autoimmune disease, or development of hematologic malignancies. Aspects of the methods also include treating a healthy individual who is a stem cell transplant donor.