| 1379000-58-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1379000-58-4
• 化学式: C₁₉H₂₅F₂N₃O₃
• 分子量: 381.423
• InChiKey: OFEVSBUPYRINBN-FVCICTRLSA-N

反应信息

• 作为产物：
  描述：

  、 N-(2-aminoethyl)-3,5-difluorobenzamide 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

  摘要：

  This Letter describes the continued optimization of the MLPCN probe molecule ML071. After introducing numerous cyclic constraints and novel substitutions throughout the parent structure, we produced a number of more highly potent agonists of the M-1 mACh receptor. While many novel agonists demonstrated a promising ability to increase soluble APP alpha release, further characterization indicated they may be functioning as bitopic agonists. These results and the implications of a bitopic mode of action are presented. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.088